High-throughput screening
Chapter 8 High-throughput screening D. Cronk Introduction: a historical and future perspective Systematic drug research began about 100 years ago, when chemistry had reached a degree of maturity that allowed…
Biopharmaceuticals
Chapter 12 Biopharmaceuticals H. LeVine Introduction The term ‘biopharmaceutical’ was originally coined to define therapeutic proteins produced by genetic engineering, rather than by extraction from normal biological sources. Its meaning…
The role of information, bioinformatics and genomics
Chapter 7 The role of information, bioinformatics and genomics B. Robson, R. McBurney The pharmaceutical industry as an information industry As outlined in earlier chapters, making drugs that can affect…
Drug development: Introduction
Chapter 14 Drug development Introduction H P. Rang, R G. Hill Introduction Drug development comprises all the activities involved in transforming a compound from drug candidate (the end-product of the…
The role of pharmaceutical marketing
Chapter 21 The role of pharmaceutical marketing V M. Lawton Introduction This chapter puts pharmaceutical marketing into the context of the complete life-cycle of a medicine. It describes the old…
Clinical development: present and future
Chapter 17 Clinical development present and future C. Keywood Introduction Clinical development is the art of turning science into medicine. It is the point at which all the data from…
Pharmacology: Its role in drug discovery
Chapter 11 Pharmacology Its role in drug discovery H P. Rang Introduction Pharmacology as an academic discipline, loosely defined as the study of the effects of chemical substances on living…
The role of medicinal chemistry in the drug discovery process
Chapter 9 The role of medicinal chemistry in the drug discovery process P. Beswick, A. Naylor Introduction Clinically the unmet need for novel and safe drugs is becoming more significant…
Choosing the target
Chapter 6 Choosing the target H P. Rang, R G. Hill Introduction: the scope for new drug targets The word ‘target’ in the context of drug discovery has several common…
Clinical imaging in drug development
Chapter 18 Clinical imaging in drug development P M. Matthews Introduction Preclinical and clinical imaging has already made a significant contribution to drug development. Almost 30% of new molecular entities…
