Granulomatous Drug Reactions
Fig. 36.1 Methotrexate nodulosis in a patient with severe long-standing rheumatoid arthritis on methotrexate for years. The nodules are seen over the proximal interphalangeal joints. They are smaller than the…
Autoimmune Bullous Diseases and Drugs
Antibiotics Antiarrythmics-antihypertensives Vaccines Actinomycin Amoxicillin Ampicillin Cephalexin Ciprofloxacin Chloroquine Dactinomycin Levofloxacin Penicillin Rifampin Ca± channel blockers Amlodipine Nifedipine ACE inhibitors Captopril Enalapril Lisinopril β-blockers Nadolol Practolol Angiotensin II antagonists Losartan…
Principles of Treatment of Cutaneous Drug Eruptions
Fig. 4.1 Exanthematous (morbilliform) drug eruption. Erythematous macules and papules, some coalescing After withdrawal of the offending medication, the rash resolves in 1–2 weeks without sequelae. Treatment is not required,…
Psoriasiform Drug Eruptions and Drugs That Flare Psoriasis
Drug-induced psoriasisiform eruption Idiopathic psoriasis Temporal association of drug initiation and onset of eruption No association with initiation of drug(s) Cessation of drug prevents disease progression No recovery after cessation…
Drug Eruptions of the Scalp
Allopurinol Beta-blockers Androgens Ergots Anticholesterol agents (statins) Hormones (OCPs, HRT) Anticoagulants Dopa Anticonvulsants Immunomodulators Antifungals Retinoids (vitamin A) Antihistamines (H2) Psychotropics Anti-inflammatory Minoxidil Anti-mitotic Heavy metals (gold) Anti-thyroid SERMS and…
Drug-Induced Delayed Multi-organ Hypersensitivity Syndrome
Fig. 25.1 Exanthem over legs developing a violaceous hue before scaling. This patient had been on clindamycin for many weeks and developed this skin eruption, which generalized with time. He…
Erythema Multiforme and Drug Reactions
Fig. 7.1 Atypical target lesions with dusky center (typical of people of color) and surrounding erythema in a patient who flares with episodes of genital HSV Historical Perspective In 1866,…
Pityriasis Rosea-Like Drug Eruptions
Drug eruption-like pityriasis rosea Gilbert’s pityriasis rosea Absence of initial single herald patch Presence of initial single herald patch Bright violet-red lesions Salmon-pink lesions Pruritus unrelieved by antihistamines Pruritus relieved…
Drug-Induced Urticaria
Fig. 6.1 Symmetric urticarial drug eruption due to cephalexin over the back. This was acute and discontinuation of the drug resulted in rapid resolution Antibiotics: penicillins, cephalosporins, macrolides, aminoglycosides, tetracyclines,…
Erythema Nodosum as a Drug Eruption
Fig. 11.1 Symmetrically distributed on the anterior shins there are erythematous, warm, indurated plaques that were confirmed to be EN on histopathology Fig. 11.2 A close-up of the lesions of…
