for Prenatal Diagnosis by Invasive Testing
Although the parents of a child with chromosomal aneuploidy may have normal chromosomes themselves, in some situations there may still be an increased risk for a chromosomal abnormality in a…
References
General References Buckingham L. Molecular diagnostics: fundamentals, methods and clinical applications. ed 2. F.A. Davis and Co: Philadelphia; 2011. Gardner RJM, Sutherland GR, Shaffer LG. Chromosome abnormalities and genetic counseling….
and Genome-Based Diagnostics
Molecular and Genome-Based Diagnostics Advances over the past few years in mutation detection have provided major improvements in risk assessment, carrier detection, and prenatal diagnosis, in many cases allowing determination…
History in Risk Assessment
Family History in Risk Assessment Family history is clearly of great importance in diagnosis and risk assessment. Applying the known rules of mendelian inheritance, as introduced in Chapter 7, allows…
References
Specific References Chen P-S, Su J-L, Hung M-C. Dysregulation of microRNAs in cancer. J Biomed Sci. 2012;19:90. Chin L, Anderson JN, Futreal PA. Cancer genomics, from discovery science to personalized…
References
General References Garraway LA, Lander ES. Lessons from the cancer genome. Cell. 2013;153:17–37. International Agency for Research on Cancer (IARC), World Health Organization. www.cruk.org/cancerstats; 2014. Schneider L. Counseling about cancer….
and the Environment
Cancer and the Environment Although the theme of this chapter emphasizes the genetic basis of cancer, there is no contradiction in considering the role of environment in carcinogenesis. By environment,…
