Type of vulvar SCC HPV-positive SCC HPV-negative SCC Age 35–65 years 55–85 years Risk factors Anogenital warts Lichen sclerosus Smoking Alcohol use Focality Multifocal Single focus Associated VIN Usual (warty/basaloid)…
Fig. 7.1 Vulvar melanosis. An asymmetric, poorly circumscribed, variegated patch mimicking melanoma is evident (left panel). Histopathologically, vulvar (genital) melanosis exhibits, in most cases, increased melanization of the basal keratinocytes,…
Dilatation of preexisting vessels Acquired lymphangiectasis Vulvar varices (venous lake) Angiokeratoma Vascular hyperplasias Pyogenic granuloma (lobular capillary hemangioma) Intravascular papillary endothelial hyperplasia (Masson’s tumor) Benign neoplasms Hemangioma Infantile hemangioma Congenital…
Fig. 11.1 Fibroadenoma. A biphasic tumor comprised of branching glandular structures within a fibrous stroma (Courtesy of Dr. Payal Kapur, Department of Pathology, University of Texas Southwestern Medical Center, Dallas,…
Subcorneal blister Staphylococcal scalded skin syndrome A microbial pustulosis of the folds (Chap. 3) Pemphigus foliaceus Intraepidermal blister Pemphigus vulgaris Papular acantholytic dyskeratosis of vulvocrural area Hailey–Hailey disease Darier’s disease…
Fig. 1.1 External genitalia of the vulva (Used with permission from Robboy et al. [22] Fig. 1.2 Perineal surface anatomy Embryology of the Female Reproductive Tract and External Genitalia The…
Fig. 8.1 Clinical vulvar melanomas present often as large lesions, with variegate pigmentation and irregular borders. Multifocality is not uncommon in vulvar melanomas Dermoscopy Dermoscopy may be used as a…
Fig. 2.1 Spongiotic pattern. Spongiosis is characterized by intraepidermal edema Acanthosis Acanthosis is defined as a thickened epidermis. Acanthosis may be “regular” with rete ridges of similar length (resembling psoriasis)…
Chapter 7Image Processing—Chemometric Approaches to Analyze Optical Molecular Images Thomas Bocklitz, Michael Schmitt, and Jürgen Popp 7.1 Introduction The principle of spectroscopic pathology presented in Chapters 3–6 is shown in…
