Large areas of fat necrosis along with variable parenchymal necrosis Saponification Hemorrhage, vascular thrombosis • Mild acute pancreatitis is most often clinical (rather than morphologic) diagnosis Spotty peripancreatic or perilobular fat…
Most often seen in children Classic syndrome involves combination of resolving viral illness and salicylate therapy Etiology/Pathogenesis • Pathogenesis unknown • Mitochondrial injury is a key feature • Frequent antecedent viral infection • Salicylate…
Glandular component may contain conventional ductal-type, clear cell, or signet ring cell components Ancillary Tests • p63 is positive in squamous component • Mucin stain, CK7, CK20, CEA, and CA19-9 highlight adenocarcinoma…
Slightly dilated and irregular in shape Lined by single layer of bland endothelial cells • Secondary involutional changes in central portion • Peripheral cellular areas show proliferation of vascular channels in loose…
Varices, ascites if portal hypertension present Jaundice variably present • Cutaneous, gastrointestinal, neuroophthalmic, musculoskeletal, renal, hematological manifestations also common • Nonspecific elevations in transaminases, alkaline phosphatase • Plasma vitamin A levels may be…
Commonly implicated drugs: Anabolic steroids, oral contraceptives, prochlorperazine, thiabendazole, warfarin • Cholestatic hepatitis: Cholestasis with inflammation and hepatocellular damage Macrolide antibiotics (erythromycin), antipsychotics (chlorpromazine), numerous other drugs • Prolonged cholestasis/ductopenia: Cholestasis >…
Portal Tract Showing Paucity of Bile DuctsPortal tract in a case of chronic ductopenic rejection contains a hepatic artery and portal vein but no interlobular bile duct. Intimal Foam Cell…
Amyloid deposits are congophilic and show “apple green” birefringence under polarized light Birefringence is best demonstrated by turning light to maximum and pulling color filters out • Immunohistochemistry P glycoprotein: Present…
Grade 3 tumors: Poorly differentiated neuroendocrine carcinoma (small or large cell type) Tumor in Ampullary RegionLow-power view shows a well-differentiated neuroendocrine neoplasm infiltrating the ampullary region. The overlying mucosa is…
