Enlarged, activated, or blastic T lymphocytes, eosinophils, and other inflammatory cells
Top Differential Diagnoses

This portal tract contains a mixed inflammatory infiltrate with activated lymphocytes, eosinophils, and plasma cells. The bile duct shows lymphocytic cholangitis and epithelial disarray



Endotheliitis



Bile duct damage

CLINICAL ISSUES
Epidemiology
• Incidence
– More frequent in younger, healthier recipients and with older donors, long cold ischemia time, and immune dysregulation of recipient
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