Enlarged, activated, or blastic T lymphocytes, eosinophils, and other inflammatory cells
Top Differential Diagnoses
This portal tract contains a mixed inflammatory infiltrate with activated lymphocytes, eosinophils, and plasma cells. The bile duct shows lymphocytic cholangitis and epithelial disarray
. The portal venule contains endotheliitis 
.
Endotheliitis
is present in a portal vein branch, characterized by inflammatory cells undermining the endothelium and lifting it up. The portal tract also contains a mild inflammatory cell infiltrate, and there is mild bile duct damage 
.
Bile duct damage
is seen in a case of acute cellular rejection. The bile duct epithelial cells show nuclear hyperchromasia, pleomorphism, uneven spacing of nuclei, and loss of polarity. The portal tract also contains a mixed inflammatory cell infiltrate.
affects a terminal hepatic vein. There is also perivenular hepatocyte necrosis 
in this case of severe acute rejection.
