Safety Pharmacology
211 New Terminology212 Safety Versus Toxicity212 Safety Pharmacology214 Early Safety Tests219 Hepatic Toxicity223 Summary225 The main aim of safety pharmacology is to define the optimal way in which potentially valuable…
Pharmacology
The Chemical Control of Physiology Outline Pharmacology and Cellular Drug Response1 New Terminology2 Pharmacological Targets2 Dose–Response Curves5 Linking Observed Pharmacology With Molecular Mechanism12 Descriptive Pharmacology: I15 Summary16 This chapter discusses…
Pituitary and Adrenocortical Hormones
DRUG CLASSES Posterior pituitary hormones • Vasopressin Anterior pituitary hormones • Gonadotropins • Somatropin • Adrenocorticotropic hormone (ACTH) Glucocorticoids Mineralocorticoids PHARMACOLOGY IN PRACTICE Janna Wong is at the clinic for a sports physical. As…
Antineoplastic Drugs
DRUG CLASSES Cell cycle–specific agents • Plant alkaloids • Taxanes • Podophyllotoxins • Camptothecin analogs • Antimetabolites Cell cycle–nonspecific agents • Alkylates • Ethyleneimines • Alkyl sulfonates • Hydrazines • Nitrosoureas • Platinum based • Antibiotics PHARMACOLOGY IN PRACTICE Patients and families…
Otic and Ophthalmic Preparations
DRUG CLASSES Otic preparations Ophthalmic Preparations PHARMACOLOGY IN PRACTICE Janna Wong, a 16-year-old high school student, recently switched from eyeglasses to contact lenses. She is experiencing minor eye irritation. In…
Antidiabetic Drugs
DRUG CLASSES Insulins Sulfonylureas Nonsulfonylureas Incretin mimetics PHARMACOLOGY IN PRACTICE When Mr. Phillip was seen for atrial fibrillation, it was discovered that he had not been seen by a health…
Menopause and Andropause Drugs
DRUG CLASSES Female hormones • Estrogens • Progestins Antispasmodics Benign prostatic Hyperplasia (BPH) Agents • α-adrenergic blockers • Androgen hormone Inhibitors • Impotence agents Hormonal cancer agents In both men…
Male and Female Hormones
DRUG CLASSES Androgens Estrogens Progestins PHARMACOLOGY IN PRACTICE Janna Wong is at the clinic for a sports physical. After the physical, Janna lingers in the examination room. You knock and…
Upper Gastrointestinal System Drugs
DRUG CLASSES Acid neutralizers Acid reducer • Histamine H2 antagonists • Proton pump inhibitors GI stimulants Antiemetics The upper GI system consists of the mouth, esophagus, and stomach (Fig. 40.1). The GI…
Anticoagulant and Thrombolytic Drugs
DRUG CLASSES Anticoagulants Antiplatelets Thrombolytics Clotting is an essential body mechanism. When a blood vessel is injured, a series of events occurs to form a clot and stop the bleeding….
