Protein cDNA changea Amino acid changeb Codon change Clinical features Transthyretin Greater than 120 mutations c Apolipoprotein AI 148G→C Gly26Arg GGC26CGC PN, Nephropathy 172G→A Glu34Lys GAA34AAA Nephropathy 178T→G Ser36Ala…
Fig. 22.1 Abdominal fat aspirate. In the middle a bundle of collagen fibers is seen and on the left, a lipid droplet in the cytoplasm of an adipocyte. Uranyl acetate,…
Fig. 29.1 Isolated atrial amyloid. Autopsy examination showed slight rigidity of the left atrial wall. (a) The cardiac myocytes show hypertrophy but no distinct eosinophilic infiltrate in the interstitial space…
Main location Amyloid protein Mother protein Prevalence Associated state or disease Different organs AL Monoclonal immunoglobulin light chain Rare Local monoclonal plasma cell clone Different organs AH Monoclonal immunoglobulin heavy…
Fig. 13.1 An artery containing amyloid stained by Congo red. In ordinary, unpolarised illumination, amyloid appears red Even with satisfactory staining by Congo red, there may be staining of normal…
Fig. 19.1 Renal biopsy diagnosed MCD showing amyloid deposition with Congo red staining Another diagnosis that may cause difficulty is that of light chain deposition disease (LCDD). Of late, we…
Fig. 9.1 (a) Amyloidosis, fibrils. (b, c) Fibrillary glomerulonephritis, fibrils. (a, b, c) Transmission electron microscopy. Uranyl acetate and lead citrate. **AX8500, BX8500. In both conditions (a, b), the fibrils…
Fig. 26.1 H&E-stained (a) normocellular bone marrow (60 % cellularity) from a 41-year-old woman with AL amyloidosis and (b) normal hematopoietic bone marrow exhibiting normal maturation of myeloid and erythroid…
Pathology Extracellular Intracellular Intra-vascular Organized Non-organized Renal Extrarenal Light chain cast nephropathy +a Amorphous + − AL/AH amyloid + Fibrillar Congo red (+) + S/L MIDD + Powdery +…
Year Reference Type of amyloid Controls Amyloid patients Sensitivity (%) Specificity (%) PPV (%) NPV (%) 1986 [15] A, L, TTR 12 12 83 100 100 86 1987 [16] A…
