Often accompanied by cholestasis • Vanishing bile duct syndrome Used to describe ductopenia related to drugs but not specific term Etiology/Pathogenesis • Many medication classes implicated Antiinflammatory, antibiotics, antiepileptics, psychiatric drugs, tranquilizers,…
Giant Cell TransformationH&E-stained section of a liver biopsy in a child with progressive familial intrahepatic cholestasis (PFIC) shows giant cell transformation of perivenular hepatocytes, typical of childhood cholestasis syndromes. Bland…
Results in different enzymatic defects in liver that are classified as glycogen storage disease (GSD) types 0, I, II, III, IV, VI, and IX Types I, III, and IX account…
Hepatitis C accounts for ∼ 20% of cases of acute hepatitis Clinical Issues • Symptoms generally mild or patients are asymptomatic Fulminant hepatic failure is rare • Most patients with acute hepatitis…
Evidence of genetic studies favors neoplastic process Likely from bone marrow-derived myeloid dendritic precursors Clinical Issues • Affects infants and children, rarely adults • Unisystem disease most often involves bone followed by…
Typically transmitted vertically, parenterally, or sexually Clinical Issues • 10% of infected patients become chronically infected 400 million people worldwide have chronic HBV • Symptoms include mild flu-like syndrome, nausea, vomiting, jaundice…
Portal vein thrombosis, systemic inflammatory conditions, some neoplasms such as renal cell carcinoma or lymphoma, artifactual sinusoidal dilatation • Other causes of parenchymal necrosis/hemorrhage Acetaminophen toxicity, ischemic liver injury Sinusoidal DilatationIn…
Most common endemic mycosis in United States • Liver involvement is almost always part of disseminated infection Patients often immunocompromised Liver is involved in up to 90% of cases of disseminated…
Clear to pale cytoplasm with sharp cell border Small, round to oval, uniform nuclei Periodic acid-Schiff without diastase has granular cytoplasmic staining • Exuberant rich capillary network immediately adjacent to epithelium…
Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues • Symptoms may present after months to years of therapy Patients may be asymptomatic despite liver injury • Due to long half-life of amiodarone, may…
