CHAPTER 22 Erythrocytosis and polycythemia J D. van der Walt Chapter contents INTRODUCTION 333 THE PATHOLOGY OF ERYTHROCYTOSIS 334 CONGENITAL ERYTHROCYTOSIS 334 Associated with reduced P50 334 High-oxygen-affinity hemoglobinopathy 334…
CHAPTER 19 Acute lymphoblastic leukemia/lymphoma and mixed phenotype acute leukemias A. Porwit, M-C. Béné Chapter Contents INTRODUCTION 289 ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA 289 Clinical presentation 289 Classification 290 Cytology, cytochemistry and…
CHAPTER 11 Iron deficiency anemia, anemia of chronic disorders and iron overload MJ. Pippard Chapter contents INTRODUCTION 173 Spectrum of pathology related to disorders of iron metabolism 174 Iron deficiency…
CHAPTER 37 Blood groups on red cells, platelets and neutrophils G. Daniels Chapter contents INTRODUCTION 599 RED CELL SURFACE ANTIGENS 599 THE ABO AND H HISTO-BLOOD-GROUP SYSTEMS AND OTHER CARBOHYDRATE…
CHAPTER 26 Systemic mastocytosis H-P. Horny Chapter contents DEFINITION 381 INTRODUCTION 381 MOLECULAR GENETICS ASPECTS 382 Important messages 382 ROUTINE WORK-UP OF CASES WITH SUSPECTED SYSTEMIC MASTOCYTOSIS 383 Bone marrow…
CHAPTER 31 Hemostasis Principles of investigation DH. Bevan, B. Sørensen Chapter contents INTRODUCTION 473 PHYSIOLOGY OF HEMOSTASIS APPLIED TO DIAGNOSIS 474 Primary hemostatis: formation of the platelet plug 474 Platelet…
CHAPTER 12 Macrocytic anemia R. Green Chapter contents MEGALOBLASTIC HEMOPOIESIS 197 Vitamin B12-related and folate-related causes of megaloblastic anemia 198 Vitamin B12 198 Folates 206 Vitamin B12-independent and folate-independent causes…
CHAPTER 34 Inherited disorders of coagulation NS. Key, JC. Boles Chapter contents INTRODUCTION 547 HEMOPHILIA 547 Inheritance 547 The molecular basis of hemophilia A and B (FVIII and FIX genes)…
CHAPTER 24 Chronic myelogenous leukemia G. Büsche, HH. Kreipe Chapter contents INTRODUCTION 361 CLINICAL FEATURES AND COURSE OF DISEASE 361 DIAGNOSTIC PROCEDURES 362 Genetics 362 Morphology 363 At diagnosis 363…
CHAPTER 9 Abnormalities of the structure and synthesis of hemoglobin SL. Thein Chapter contents INTRODUCTION 131 NORMAL HUMAN HEMOGLOBIN: STRUCTURE AND SYNTHESIS 131 INHERITED DISORDERS OF HEMOGLOBIN 133 THALASSEMIAS 134…
