Physical Chemistry

Jan 10, 2017 by in PHARMACY Comments Off on Physical Chemistry

Tetracycline hydrochloride 5.0 g Methyl parahydroxybenzoate 0.1 g Sodium citrate 6.5 g Sorbitol, liquid (crystallising) 65.5 g Tragacanth 0.5 g Water, purified 40.0 g Total 118.2 g (= 100 mL) Chloramphenicol has an extremely bitter taste. When this antibiotic…

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Documentation

Jan 10, 2017 by in PHARMACY Comments Off on Documentation

Fig. 33.1 Structure of a documentation system The purpose of the various documents is as follows: Quality manual (see Sect. 35.​6.​1): the quality manual describes the quality system of the…

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Raw Materials

Jan 10, 2017 by in PHARMACY Comments Off on Raw Materials

Substance Bruto formula Molecular mass 1 mg substance = base (mg) Codeine (pure substance) C18H21NO3 299.4 1 Codeine. H2O (Ph. Eur.) C18H21NO3.H2O 317.4 0.94 Codeine phosphate.½H 2 O (Ph. Eur.) C 18 H…

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Sterilisation Methods

Jan 10, 2017 by in PHARMACY Comments Off on Sterilisation Methods

(30.1) or after integration (30.2)or (30.3)In these equations N is the number of living micro-organisms at time 0 and time t respectively, k is the first-order reaction constant, and D…

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Equipment

Jan 10, 2017 by in PHARMACY Comments Off on Equipment

Fig. 28.1 Schematic construction of exhaust and air filtering equipment (= Fig. 28.1a–g). Source: Recepteerkunde 2009, ©KNMP For the protection of the operator and co-workers the most basic engineering control…

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Stability

Jan 10, 2017 by in PHARMACY Comments Off on Stability

Fig. 22.1 pH stability relationship for acetylsalicylic acid solution [11] Hydrolysis is not only dependent on the pH (catalysis by H+ or OH− ions), but may also be catalysed by…

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Premises

Jan 10, 2017 by in PHARMACY Comments Off on Premises

A. Stock preparations Categories A1 Sterile  Aseptic preparations (vials, ampoules, infusion fluids in bags, prefilled syringes) III Autoclavable preparations (vials, ampoules, infusion fluids in bags or bottles) III Eye drops…

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Pulmonary

Jan 10, 2017 by in PHARMACY Comments Off on Pulmonary

Fig. 6.1 Principle variables and interactions in pulmonary administration of medicines For many inhalation devices, the inhalation manoeuvre has an influence on the aerosol generation process. Either the air stream…

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Containers

Jan 10, 2017 by in PHARMACY Comments Off on Containers

  Minimal temperature °C Maximal temperature °C   Long time Short time Long time HDPE −50 90/120 70/80 LDPE −50 80/90 60/75 PET −20 80 65 PP 0/−30 140 100 COC…

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Basic Operations

Jan 10, 2017 by in PHARMACY Comments Off on Basic Operations

Fig. 29.1 Schematic representation of accuracy and precision. (a) High accuracy and high precision, good balance in repeatability; (b) High accuracy and low precision, measured values are wide-spread; (c) Low…

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