Collagen Vascular Diseases and Cutaneous Drug Reactions
Fig. 16.1 Annular plaque on the breast of a woman who was on methyldopa. The biopsy was compatible with DLE. The patient was histone positive and improved when the drug…
Drug-Induced Vasculitis
Fig. 8.1 Leukocytoclastic vasculitis secondary to anti-thymocyte globulin in the setting of serum sickness Drugs Associated with Vasculitis Hydralazine Minocycline Isotretinoin Methimazole D-penicillamine Hydralazine Levamisole Penicillin Cephaolosporins Methotrexate Cocaine Propylthiouracil…
Pediatric Drug Eruptions of the Skin
Fig. 38.1 Angioedema in a young boy. Drugs should always be considered as an underlying etiology Histopathology Acute urticaria consists of interstitial edema, dilated venules with endothelial swelling, and minimal…
Acute Generalized Exanthematous Pustulosis
Fig. 26.1 Generalized edematous, erythematous rash preceding pustule presentation. Fig. 26.2 Non-follicular, sterile, pinpoint pustules characteristic of acute generalized exanthematous pustulosis Fig. 26.3 Bullous lesions and lakes of pus In…
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
Fig. 24.1 Dusky red discoloration with trunkal involvement that is often seen early in TEN. Early desqumation is starting over lower abdominal panniculus. Reaction was to Bactrim Early cutaneous findings…
Cutaneous Reactions to Retinoids
Fig. 34.1 Severe dryness and fissuring of lips and nose in a patient on isotretinoin Fig. 34.2 Xerotic skin with reticulate fissuring seen in asteatotic dermatitis over the ankle in…
Drug-Induced Photosensitivity
Phototoxicity Photoallergy Incidence High Low Amount of agent required for photosensitivity Large Small Onset after exposure to photosensitizer and light Minutes to hours 24 h or more Occurs after…
Acne and Drug Reactions
Fig. 15.1 Primary lesions Secondary Lesions Comedones and cysts can arise secondary to inflammatory papules and pustules but are often not present. Pits and scars are evident in severe cases….
Antiepileptic Medications and Cutaneous Drug Reactions
Fig. 28.1 Symmetric, erythematous morbilliform drug reaction in a patient with DRESS syndrome Drug is high risk, such as an aromatic AED Fever Liver abnormalities or other organ involvement Leukocyte…
Drug Eruptions and Erythroderma
Diseases commonly associated with or preceding erythroderma a Dermatologic diseases Psoriasis Atopic dermatitis Pityriasis rubra pilaris Contact and other types of dermatitis Dermatophytosis Ichthyosis Pemphigus foliaceus Systemic diseases Lymphoma: CTCL,…
