Bartter Syndrome Shane M. Meehan, MBBCh Key Facts Terminology Normotensive hyper-reninemic hyperaldosteronism with hypokalemic alkalosis and hyperplasia of juxtaglomerular apparatus Etiology/Pathogenesis 5 types of loss-of-function mutations of genes affecting ion…
Endocarditis A. Brad Farris, III, MD Key Facts Terminology GN following infection of heart valves Etiology/Pathogenesis Subacute bacterial endocarditis (SBE) e.g., Streptococcus viridans infecting a rheumatic heart Acute bacterial endocarditis…
Karyomegalic Interstitial Nephritis Robert B. Colvin, MD Key Facts Etiology/Pathogenesis Idiopathic Genetic risk factor suspected, but unproved DNA toxins suspected in some cases (ochratoxin) Clinical Issues Rare; < 30 cases…
Type III Collagen Glomerulopathy Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Idiopathic glomerular disease defined by accumulation of mesangial and subendothelial type III collagen Clinical Issues Rare…
Mitochondriopathies Surya V. Seshan, MD Key Facts Etiology/Pathogenesis Rare genetic disorder of mtDNA Drug induced with reverse transcriptase inhibitors Clinical Issues Clinically, biochemically and genetically heterogeneous 50% have renal involvement…
Miscellaneous HIV-associated Renal Diseases A. Brad Farris, III, MD Lupus-like GN is one of the more frequent diseases associated with HIV, typically showing a markedly expanded mesangium , thickened capillary…
Light Chain Fanconi Syndrome Lynn D. Cornell, MD Key Facts Terminology Chronic tubulointerstitial nephropathy caused by intracytoplasmic crystalline inclusions composed of monoclonal light chains present in proximal tubular epithelial cells…
Aristolochic Acid Nephropathy Shane M. Meehan, MBBCh Key Facts Terminology Progressive tubulointerstitial nephropathy and urothelial carcinoma related to aristolochic acid in herbal remedies Etiology/Pathogenesis Patients give history of intake of…
Focal Segmental Glomerulosclerosis, Secondary A. Brad Farris, III, MD Key Facts Terminology FSGS secondary to imbalance of glomerula-functional capacity and demand Etiology/Pathogenesis Adaptive structural-functional response Reduced nephron mass: Oligomeganephronia, reflux…
Type III Hyperlipoproteinemia Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis APOE2 homozygotes Autosomal recessive Clinical Issues Males more commonly affected Nephrotic syndrome Premature vascular disease Palmar and…
