Aristolochic Acid Nephropathy



Aristolochic Acid Nephropathy


Shane M. Meehan, MBBCh










Early features of aristolochic acid nephropathy include acute tubular injury, early tubular atrophy, and diffuse fine interstitial fibrosis with little inflammation. Glomeruli are spared.






Tubules are shrunken, and there is widening of the interstitial compartment with myxoid matrix accumulation and characteristically minimal infiltrate of mononuclear cells.


TERMINOLOGY


Abbreviations



  • Aristolochic acid nephropathy (AAN)


Synonyms



  • Chinese herb nephropathy


Definitions



  • Tubulointerstitial nephropathy and urothelial carcinoma associated with exposure to aristolochic acid in herbal remedies


ETIOLOGY/PATHOGENESIS


Plant-derived Toxin from Genus Aristolochia

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aristolochic Acid Nephropathy
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