Aristolochic Acid Nephropathy

Aristolochic Acid Nephropathy

Shane M. Meehan, MBBCh

Early features of aristolochic acid nephropathy include acute tubular injury, early tubular atrophy, and diffuse fine interstitial fibrosis with little inflammation. Glomeruli are spared.

Tubules are shrunken, and there is widening of the interstitial compartment with myxoid matrix accumulation and characteristically minimal infiltrate of mononuclear cells.



  • Aristolochic acid nephropathy (AAN)


  • Chinese herb nephropathy


  • Tubulointerstitial nephropathy and urothelial carcinoma associated with exposure to aristolochic acid in herbal remedies


Plant-derived Toxin from Genus Aristolochia

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aristolochic Acid Nephropathy
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