Karyomegalic Interstitial Nephritis

Karyomegalic Interstitial Nephritis

Robert B. Colvin, MD

Karyomegalic interstitial nephritis has focal, enlarged, abnormal tubular epithelial nuclei image accompanied by tubular atrophy, glomerulosclerosis, interstitial inflammation and fibrosis. (Courtesy A. Friedl, MD.)

In KIN, enlarged, hyperchromatic nuclei are most prominent in tubular cells. Similar nuclear changes occur in most other organs, including liver, lung, brain, and endocrine glands. (Courtesy G. Monga, MD.)



  • Karyomegalic interstitial nephritis (KIN)


  • Systemic karyomegaly


  • Chronic tubulointerstitial nephritis with prominent karyomegaly in tubular epithelium

  • Initially reported by Mihatsch and colleagues in 1979


Sporadic and Familial Cases

  • Genetic risk factor suspected, but unproved

  • Possible association with HLA (B27/35)

Environmental Toxins

  • Suspected in some cases

  • Ochratoxin has been implicated in cases in Tunisia

Animal Models

  • Various toxins in rats

    • Ochratoxin

    • Cisplatin

    • Glutathione depletion (1-cyano-3,4-epithiobutane)

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Karyomegalic Interstitial Nephritis

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