Basicmedical Key

Bacillary Angiomatosis Roberto N. Miranda, MD Key Facts Terminology Nodules of small blood vessels resulting from infection by bacterium Bartonella henselae Etiology/Pathogenesis B. henselae and B. quintana are most common…

Histoplasma Lymphadenitis Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis Histoplasma is endemic in Central America River valleys of midwestern and south-central USA Acute disseminated disease occurs in Immunocompromised subjects including AIDS…

Infectious Mononucleosis Pei Lin, MD Key Facts Etiology/Pathogenesis Epstein-Barr virus infection Clinical Issues Fever Pharyngitis Lymphadenopathy Microscopic Pathology Follicular and interfollicular hyperplasia Range of cells from small mature forms to…

Cat Scratch Disease Roberto N. Miranda, MD Key Facts Terminology Necrotizing inflammation caused by Bartonella henselae Etiology/Pathogenesis Bartonella henselae causes most cases of CSD 90% of patients report contact with…

Mycobacterium tuberculosis Lymphadenitis Tariq Muzzafar, MBBS Key Facts Clinical Issues High index of suspicion essential for diagnosis Definitive diagnosis by histology and culture of LN Molecular methods enable quicker identification…

Whipple Disease Sa A. Wang, MD Key Facts Etiology/Pathogenesis T. whipplei, gram-positive bacilli related to Actinomycetes Engulfed by tissue macrophages Systemic disease; affects many organ systems Exerts no visible cytotoxic…

Syphilitic Lymphadenitis Francisco Vega, MD, PhD Key Facts Terminology Syphilis: Chronic systemic infection caused by T. pallidum (Gram-negative spirochete) Clinical Issues Course of disease divided into 3 stages: Primary, secondary,…

Mycobacterial Spindle Cell Pseudotumor Tariq Muzzafar, MBBS Key Facts Clinical Issues Rare entity; predominantly in young men History of immunosuppression and HIV infection Microscopic Pathology Spindle cells arranged in fascicles…

Atypical Mycobacterial Lymphadenitis Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis Peak incidence at 1-5 years M. avium-intracellulare (in 80% of cases in children) M. scrofulaceum, M. malmoense, and M. haemophilum Uncommon…

Chronic Granulomatous Lymphadenitis C. Cameron Yin, MD, PhD Key Facts Terminology Granulomatous inflammation is specific type of inflammatory response Characterized by accumulation of modified macrophages (epithelioid cells) Initiated by infectious…