Dermatofibroma and Fibrous Histiocytoma David Cassarino, MD, PhD Key Facts Terminology Benign, limited proliferation of histiocytic and fibroblastic cells in dermis Etiology/Pathogenesis Evidence supports both neoplastic and reactive pathogenesis Clinical…
Epithelioid Cell Histiocytoma David Cassarino, MD, PhD Key Facts Terminology Dermal-based benign fibrohistiocytic tumor, which can mimic melanocytic, vascular, epithelial, or other histiocytic lesions Clinical Issues Usually occur in young…
Acral Fibrokeratoma Steven D. Billings, MD Key Facts Microscopic Pathology Dome-shaped to elongated silhouette Epidermis is hyperkeratotic and acanthotic Relatively hypocellular proliferation of fibroblasts Vertically oriented thick collagen bundles Top…
Angiofibroma and Related Lesions Steven D. Billings, MD Key Facts Clinical Issues Fibrous papule Adenoma sebaceum: Angiofibromas associated with tuberous sclerosis Solitary dome-shaped flesh-colored papules on nose or central face…
Juvenile Hyaline Fibromatosis Elizabeth A. Montgomery, MD Key Facts Terminology Juvenile hyaline fibromatosis (JHF) Related disorder: Infantile systemic hyalinosis (ISH) Clinical Issues Autosomal recessive transmission Infantile presentation of lesions of…
Fibromatosis Elizabeth A. Montgomery, MD Key Facts Terminology Deep fibromatosis: Desmoid tumor Palmar fibromatosis: Dupuytren contracture Plantar fibromatosis: Ledderhose disease Penile fibromatosis: Peyronie disease Myofibroblastic proliferations with infiltrative growth pattern…
Sclerotic Fibroma David Cassarino, MD, PhD Key Facts Terminology Storiform collagenoma Benign, dermal-based fibroblastic proliferation Microscopic Pathology Composed of thickened, hyalinized-appearing collagen bundles in storiform/whorled pattern Occasional cases may show…
Collagenous Fibroma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Rare, benign, fibrous soft tissue neoplasm occurring mainly in adult males and consisting of paucicellular arrays of stellate and spindled…
Keloid and Cellular Scar David Cassarino, MD, PhD Key Facts Terminology Scar with prominent thickened and eosinophilic bundles of collagen Clinical Issues Persistence and recurrence are common, but no risk…
Metastatic Tumors to the Skin Christine J. Ko, MD David Cassarino, MD, PhD Key Facts Clinical Issues Cutaneous metastases often located near primary tumor site Incidence rate of ˜ 2-10%…
