Keloid and Cellular Scar



Keloid and Cellular Scar


David Cassarino, MD, PhD










Clinical photograph shows multiple keloids on the shoulder and upper arm of this patient.






High-power examination of a keloid shows a proliferation of thickened, hyalinized eosinophilic collagen bundles with increased numbers of stromal fibroblasts. Collagen bundles are randomly oriented and unevenly distributed.


TERMINOLOGY


Synonyms



  • Scar with keloidal collagen


Definitions



  • Scar with prominent thickened and eosinophilic bundles of collagen extending beyond original wound


ETIOLOGY/PATHOGENESIS


Unknown, Possibly Genetic



  • Fibroblasts from keloids show decreased apoptosis


  • Many cytokines implicated in stimulating fibroblasts, including TGF-B and IL-15


CLINICAL ISSUES


Epidemiology



  • Age



    • Most common in patients < 30 years


  • Ethnicity



    • More common in African-American patients; least common in Caucasians


Site



  • Earlobe is most common site



    • Typically follows ear piercing or other trauma

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Keloid and Cellular Scar
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