Elizabeth A. Montgomery, MD

Gross photograph shows a large, deep fibromatosis of the shoulder that has eroded into the scapula. Superficial portions of such lesions can be encountered on skin biopsies.

Hematoxylin & eosin shows sweeping fascicles of spindle cells separated by regularly spaced collagen. Even at this magnification, small vessels are readily apparent image.



  • Deep fibromatosis: Aggressive fibromatosis, desmoid tumor

  • Superficial fibromatoses: Palmar fibromatosis (Dupuytren contracture, Dupuytren disease), plantar fibromatosis (Ledderhose disease), penile fibromatosis (Peyronie disease), knuckle pads


  • Palmar fibromatosis: Nodular myofibroblastic proliferation of volar surface of hand that is prone to local persistence, but does not metastasize

  • Plantar fibromatosis: Nodular myofibroblastic proliferation of plantar surface of foot that is prone to local persistence, but does not metastasize

  • Peyronie disease: Penile fibrous lesion causing various deformities; initially pain with erection, erectile dysfunction

  • Knuckle pads: Well-circumscribed thickening of skin over metacarpophalangeal and, more commonly, proximal interphalangeal joints

  • Deep fibromatosis: Myofibroblastic proliferation of deep soft tissues with infiltrative growth pattern; prone to local recurrences, but does not metastasize



  • Incidence

    • Palmar fibromatosis

      • 4-6% of Caucasian adults > 50 years of age; reports of up to 75% of Celtic males

      • Uncommon in nonwhites; marked male predominance

    • Plantar fibromatosis

      • 1-2 per 100,000 persons per year (northern Europe)

      • Most patients 30-50 years of age; slight male predominance

    • Penile fibromatosis

      • About 3.5% of white men > 50 years of age

    • Deep fibromatosis

      • 2.4-4.43 new cases per 100,000 persons per year (Scandinavian data)

    • Knuckle pads (rare)

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibromatosis

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