Basicmedical Key

Nasal Glial Heterotopia Lester D. R. Thompson, MD Key Facts Etiology/Pathogenesis Congenital malformation of displaced normal and mature glial tissue Clinical Issues Separated into extranasal and intranasal types NGH usually…

Perineurioma Lester D. R. Thompson, MD Key Facts Terminology Benign peripheral nerve sheath tumor, specifically of perineurial cell derivation that surrounds endoneurial connective tissue space of nerve fibers Etiology/Pathogenesis May…

Fibrolipomatous Hamartoma of Nerve Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Increased fibrofatty tissue infiltrating and surrounding nerves Clinical Issues Median nerve most commonly affected Predominantly in children, including…

Granular Cell Tumor Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign tumor composed of poorly demarcated accumulation of plump granular cells Thought to arise from Schwann cells Granular cell…

Angiosarcoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Malignant mesenchymal neoplasm of cells recapitulating variable morphologic and functional features of endothelial cells Clinical Issues Deep soft tissues Lower extremities,…

Cellular Neurothekeoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Multinodular dermal tumor composed of nests of rounded cells separated by delicate fibrous septa Differs from dermal nerve sheath myxoma…

Schwannoma (Neurilemmoma) Amitabh Srivastava, MD Key Facts Terminology Encapsulated, benign peripheral nerve sheath tumor composed predominantly of Schwann cells Clinical Issues Common between 20-50 years of age Affects males and…

Neurofibroma Amitabh Srivastava, MD Key Facts Terminology Benign peripheral nerve sheath tumor with heterogeneous admixture of axons, Schwann cells, perineurial cells, and fibroblasts Most are sporadic; neurofibromatosis type 1 (NF1)…

Neuromas Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Neuroma represents proliferation of peripheral nerve fibers in which ratio of axons to Schwann cell fascicles approaches 1:1 Solitary circumscribed neuroma…

Kaposi Sarcoma Thomas Mentzel, MD Key Facts Terminology Locally aggressive endothelial neoplasm associated with human herpes virus 8 Clinical Issues Most typical site of involvement is skin Mucosal membranes, lymph…