Fibrolipomatous Hamartoma of Nerve



Fibrolipomatous Hamartoma of Nerve


Cyril Fisher, MD, DSc, FRCPath










MR of the wrist shows an abnormal fat signal image in the stroma between the nerve fascicles (black dots) of an enlarged median nerve.






Histologic examination shows an accumulation of mature adipose tissue with hypocellular fibrous septa around and between nerve bundles.


TERMINOLOGY


Synonyms



  • Lipofibromatous hamartoma of nerve


  • Neural fibrolipoma


  • Neurolipomatosis, lipomatosis of nerve


Definitions



  • Increased fibrofatty tissue infiltrating and surrounding subcutaneous and, rarely, deep nerves


CLINICAL ISSUES


Epidemiology



  • Age



    • Predominantly in children, including congenitally


    • Some cases in young adults up to 30 years of age


    • Rarely in older adults


Site



  • Affects palmar surface, wrist, forearm


  • Median nerve and branches most commonly affected


  • Rarely involves ulnar or radial nerve


  • Involves left arm > right arm


  • Very rarely involves sciatic, peroneal, or cranial nerve

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibrolipomatous Hamartoma of Nerve
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