Fibrolipomatous Hamartoma of Nerve

Fibrolipomatous Hamartoma of Nerve

Cyril Fisher, MD, DSc, FRCPath

MR of the wrist shows an abnormal fat signal image in the stroma between the nerve fascicles (black dots) of an enlarged median nerve.

Histologic examination shows an accumulation of mature adipose tissue with hypocellular fibrous septa around and between nerve bundles.



  • Lipofibromatous hamartoma of nerve

  • Neural fibrolipoma

  • Neurolipomatosis, lipomatosis of nerve


  • Increased fibrofatty tissue infiltrating and surrounding subcutaneous and, rarely, deep nerves



  • Age

    • Predominantly in children, including congenitally

    • Some cases in young adults up to 30 years of age

    • Rarely in older adults


  • Affects palmar surface, wrist, forearm

  • Median nerve and branches most commonly affected

  • Rarely involves ulnar or radial nerve

  • Involves left arm > right arm

  • Very rarely involves sciatic, peroneal, or cranial nerve

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibrolipomatous Hamartoma of Nerve
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