Basicmedical Key

Diffuse Large Cell Lymphoma of the Mediastinum Key Facts Clinical Issues Predominantly affects women in 3rd decade of life Presents with rapidly growing, large (> 10 cm in diameter), infiltrative…

Atypical Thymoma Key Facts Terminology WHO type B3, polygonal cell thymoma, well-differentiated thymic carcinoma Moderately differentiated thymic epithelial neoplasm intermediate between thymoma and thymic carcinoma Microscopic Pathology Confluent sheets of…

Thymoma Key Facts Clinical Issues Majority of thymomas are very low-grade malignant neoplasms with generally indolent behavior Status of capsular integrity is most important determinant factor for prognosis Microscopic Pathology…

Ganglioneuroma Key Facts Terminology Ganglioneuroma (GN) Benign tumor of neural origin Clinical Issues Incidence Tumor is more common in young patients Location More common in posterior mediastinum Symptomatology Chest pain…

Castleman Disease Key Facts Clinical Issues Most common in 3rd decade of life Localized type Presents as large mass involving lymph node or lymph node group Many patients are asymptomatic,…

Ependymoma Key Facts Terminology Neural neoplasm of possible intermediate malignant potential when in mediastinum Etiology/Pathogenesis Probably derived from paravertebral ependymal rests Clinical Issues Incidence Ependymomas arising in mediastinum are rare…

Mediastinal Seminoma Key Facts Terminology Thymic seminoma Etiology/Pathogenesis Probably misplaced germ cells in anterior mediastinum Clinical Issues Incidence May account for approximately 37% of all germ cell tumors Majority of…

Mediastinal Teratoma Key Facts Etiology/Pathogenesis Some authors have proposed the possibility of ectopically misplaced germ cells Clinical Issues Incidence Most common germ cell tumors in anterior mediastinum Approximately 45% of…

Alveolar Soft Part Sarcoma Key Facts Clinical Issues Incidence Extremely rare tumor in mediastinal compartment Appears to be more common in young adults in 3rd decade of life More common…

Leiomyosarcoma Key Facts Clinical Issues Incidence More common in adults Range: 25-70 years of age Anatomic site Tumor may appear in anterior or posterior mediastinum Treatment Complete surgical resection of…