USAN: Sitagliptin Phosphate Brand Name: Januvia (Merck) Molecular Weight: 523.32 (Parent, 407.31) FDA Approval: 2006 Drug Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor Indications: Type II Diabetes Mechanism of Action: Competitive and…
USAN: Sofosbuvir Brand Name: Sovaldi (Gilead) Molecular Weight: 529.46 FDA Approval: 2013 Drug Class: Phosphoramide Prodrug of Antiviral Nucelotide Indications: Hepatitis C Virus (HCV) Infection Mechanism of Action: HCV NS5B…
USAN: Imatinib Mesylate Brand Name: Gleevec (Novartis) Molecular Weight: 589.71 (Parent, 493.60) FDA Approval: 2001 Drug Class: Protein-tyrosine Kinase Inhibitor Indications: Treatment of Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal…
USAN: Esomeprazole Brand Name: Nexium (AstraZeneca) Molecular Weight: 713.13 FDA Approval: 2001 Drug Class: Anti-Ulcer Indications: Gastroesophageal Reflux Disease (GERD) Mechanism of Action: Proton Pump Inhibitor (H+/K+-ATPase Inhibitor) ■ 1…
USAN: Clopidogrel Bisulfate Brand Name: Plavix (Sanofi-Aventis/Bristol-Myers Squibb) Molecular Weight: 419.90 (Parent 321.06) FDA Approval: 1993 Drug Class: Anti-Platelet Indications: Antithrombotic, Blood Thinner Mechanism of Action: Antagonist of the P2Y12…
USAN: Paclitaxel Brand Name: Taxol (Bristol-Myers Squibb) Molecular Weight: 839.92 FDA Approval: 1992 Drug Class: Anticancer Indications: Ovarian, Breast, and Non–Small-Cell Lung Cancer; Kaposi’s Sarcoma Mechanism of Action: Microtubule-stabilizing Agent…
USAN: Duloxetine Hydrochloride Brand Name: Cymbalta (Eli Lilly) Molecular Weight: 277.41 (Parent, 333.88) FDA Approval: 1994 Drug Class: Selective Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) Antidepressant Indications: Major Depressive Disorder,…
USAN: Atorvastatin Calcium Brand Name: Lipitor (Pfizer) Molecular Weight: 1155.37 (Parent 557.25) FDA Approval: 1996 Drug Class: Statins Indications: Lower Blood Cholesterol in Low-Density Lipoprotein (LDL) Mechanism of Action: Inhibitor…
USAN: Olanzapine Brand Name: Zyprexa (Eli Lilly) Molecular Weight: 312.43 FDA Approval: 1996 Drug Class: Atypical Antipsychotic Drug Indications: Schizophrenia and Bipolar Disorder Mechanism of Action: Serotonin–Dopamine Antagonist (SDA) ■…
USAN: Amlodipine Besylate Brand Name: Norvasc (Pfizer) Molecular Weight: 567.06 (Parent 408.88) FDA Approval: 1990 Drug Class: 1,4-Dihydropyridine Calcium Channel Blocker Indications: Treatment of Hypertension and Angina Pectoris Mechanism of…
