Principles of Inflammation and the Immune System

Aug 3, 2016 by in PHARMACY Comments Off on Principles of Inflammation and the Immune System

   INTRODUCTION Inflammation and the immune system are closely intertwined. Inflammation is composed of a complex web of responses to tissue injury and infection, characterized by the classic signs of rubor…

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Drug Toxicity

Aug 3, 2016 by in PHARMACY Comments Off on Drug Toxicity

Drug Toxicity Michael W. Conner, Catherine Dorian-Conner, Vishal S. Vaidya, Laura C. Green, and David E. Golan INTRODUCTION & CASE MECHANISMS OF DRUG TOXICITY On-Target Effects Off-Target Effects Idiosyncratic Toxicity…

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Local Anesthetic Pharmacology

Aug 3, 2016 by in PHARMACY Comments Off on Local Anesthetic Pharmacology

   INTRODUCTION Local anesthetics (LAs) are a class of locally applied chemicals, with similar molecular structures, that can disrupt nerve transmission, inhibit the perception of sensations (importantly, pain), blunt autonomic activity,…

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Integrative Inflammation Pharmacology: Gout

Aug 3, 2016 by in PHARMACY Comments Off on Integrative Inflammation Pharmacology: Gout

   INTRODUCTION Gout is a uniquely human disease. Most mammals possess uricase, an enzyme that metabolizes purine breakdown products into a freely water-soluble substance, allantoin. Humans, in contrast, excrete most purines…

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Pharmacology of Fungal Infections

Aug 3, 2016 by in PHARMACY Comments Off on Pharmacology of Fungal Infections

   INTRODUCTION Fungi are free-living microorganisms that exist as yeasts (single-cell, round fungi), molds (multicellular filamentous fungi), or a combination of the two (so-called dimorphic fungi). All fungi are eukaryotic organisms….

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Pharmacology of Hematopoiesis and Immunomodulation

Aug 3, 2016 by in PHARMACY Comments Off on Pharmacology of Hematopoiesis and Immunomodulation

Pharmacology of Hematopoiesis and Immunomodulation Andrew J. Wagner, Ramy A. Arnaout, and George D. Demetri INTRODUCTION & CASE PHYSIOLOGY OF HEMATOPOIESIS Central Role of Hematopoietic Growth Factors Multilineage Growth Factors…

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Drug Delivery Modalities

Aug 3, 2016 by in PHARMACY Comments Off on Drug Delivery Modalities

   INTRODUCTION Drugs are typically administered in either pill or injection form, with limited control over release rate and localization. More advanced drug delivery systems have recently been developed, however. The…

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Principles of Nervous System Physiology and Pharmacology

Aug 3, 2016 by in PHARMACY Comments Off on Principles of Nervous System Physiology and Pharmacology

Principles of Nervous System Physiology and Pharmacology Joshua M. Galanter, Susannah B. Cornes, and Daniel H. Lowenstein INTRODUCTION & CASE NEUROANATOMY Anatomy of the Peripheral Nervous System Autonomic Nervous System…

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Environmental Toxicology

Aug 3, 2016 by in PHARMACY Comments Off on Environmental Toxicology

   INTRODUCTION Environmental toxicology is the study of deleterious effects of physical, chemical, or microbiological agents present in air, water, food, or other media. In this context, airborne exposures include those…

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Systematic Detection of Adverse Drug Events

Aug 3, 2016 by in PHARMACY Comments Off on Systematic Detection of Adverse Drug Events

Systematic Detection of Adverse Drug Events Jerry Avorn INTRODUCTION & CASE CHALLENGES IN THE ASCERTAINMENT OF DRUG SAFETY Study Size and Generalizability Surrogate Outcomes and Comparators Duration and Postapproval Studies…

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