Antidepressant class adjusted hazard ratio (95 % CI) SSRIs TCAs Others Not taking antidepressants Adverse outcomes All-cause mortality 1.54 (1.48–1.59) 1.16 (1.10–1.22) 1.66 (1.56–1.77) 1.00 Attempted suicide/self-harm 2.16 (1.71–2.71)…
CPRD THIN IPCI BIFAP HSD Arianna Pedianet Country/region UK UK The Netherlands Spain Italy Italy Italy Population General population, including adults and children Pediatric and adult population Pediatric population…
Year withdrawn Drug (generic name) Reason withdrawn 1982 Clomacron Hepatotoxicity (UK) 1983 Zimeldine Hypersensitivity, Guillain-Barre syndrome (worldwide) 1986 Nomifensine Hemolytic anemia (worldwide) 1991 Triazolam Depression, amnesia (UK, France, and other…
© Springer International Publishing Switzerland 2016Edoardo Spina and Gianluca Trifirò (eds.)Pharmacovigilance in Psychiatry10.1007/978-3-319-24741-0_1 1. Pharmacovigilance in Psychiatry: An Introduction Edoardo Spina1 , Gianluca Trifirò1 and Achille Patrizio Caputi1 (1) Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy…
Fig. 3.1 Dilution bias: cumulative (left) and instantaneous (right) reporting rates for death by suicide among all reports for three antidepressants in the UK. After a TV show discussed this…
