Fig. 6.1 Dose-dependent plasma concentrations of amisulpride in 179 schizophrenic patients treated and observed under everyday conditions. Drug concentrations are highly variable. Under recommended doses of 400–800 mg/day, many patients…
Study Characteristics PEM M-PEM SCEM Setting Primary care Secondary care Prescribers General Practitioner Specialist Design Non-interventional observational cohort Data Source Secondary use of data from existing medical records Ethics Waiver…
ADE AMP (%) (5; 1,226)a MPH (%) (16; 2,092)a ATX (%) (21; 3,127)a GUA (%) (6; 1,150)a CLO (%) (1; 154)a Irritability 7–82 1–80 2–12 6–7 8 Crying 76 2–71…
Light gray: Generally considered safe, but uncertainties may exist, e.g., for some of the drugs within a group or related to the total amount of data available Medium gray: Increased…
Gene Polymorphism(s) Drug/drug class Type of ADR Comment on evidence HLA–B HLA-B*1502 Carbamazepine Stevens-Johnson syndrome Recommended in Asian ancestry CYP2D6 Partially or totally inactive alleles Pimozide Arrhythmia Recommended for doses…
© Springer International Publishing Switzerland 2016Edoardo Spina and Gianluca Trifirò (eds.)Pharmacovigilance in Psychiatry10.1007/978-3-319-24741-0_14 14. Safety of Psychotropic Drugs in the Elderly Kate L. Lapane1 , Anne Hume2, 3 , Christine Ulbricht1 and Giovanni Gambassi4 (1) Department of Quantitative Health Sciences, Division of…
Antipsychotic drug Indication FDA approval patient age (years) EMA approval patient age (years) FGAs Haloperidola Schizophrenia – ≥3b Behavioral disorders (hyperactivity, aggression) – ≥3b Gilles de la Tourette syndrome –…
Lithium N (%) Therapeutic agent toxicity 601 (2.3 %) Tremor 525 (2.01 %) Drug interaction 477 (1.82 %) Confusional state 337 (1.29 %) Completed suicide 299 (1.14 %) Drug…
Common Less common Rare Anxiety Muscle pain Convulsions Insomnia Vomiting Delirium Dysphoria Hyperacusis Psychotic symptoms Excitability Photophobia Delusions Poor memory and concentration Altered sensation Hallucinations Dizziness Depersonalization Mania Gastrointestinal problems…
Drug D2 5HT2A M H1 Alpha-1 Adverse side-effect association Reference compound Spiperone 4 – – – – EPS, tardive dyskinesia, prolactin Ketanserin – 4 – – – Rhabdomyolysis 3-quinuclidinyl-4-iodobenzilate (QNB)…
