Morphologic Evaluation
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Morphologic evaluation can be approached by recognizing lineage-specific features and formulating a differential diagnosis…
Immunoperoxidase Studies
Fig. 4.1 Immunostaining using direct smear when cell block is not available (example 1): smears of a squamous carcinoma do not show typical diagnostic features; the diagnosis was confirmed by…
Introduction
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Fine-needle aspiration (FNA) is a safe, simple, rapid, and cost-effective procedure that allows the…
Sample Collection, Preparation, Rapid On-Site Evaluation, and Triage
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Sample Collection and Preparation The success of an FNA procedure depends on the nature…
Flow Cytometric Immunophenotyping
Fig. 5.1 Multicolor flow cytometric immunophenotyping on fine-needle aspiration sample (example 1): the histogram shows coexpression of CD19 and CD5, an important feature of mantle cell lymphoma Fig. 5.2 Multicolor…
Cytogenetic Studies
Tumor type Cytogenetic change Fusion protein Alveolar soft part sarcoma t(X;17)(p11;q25) ASPL–TFE3 Clear cell sarcoma/melanoma of soft parts t(12;22)(q13;q12) EWS–ATF1 t(2;22)(q34;q12) EWS–CREB1 Chondrosarcoma, extraskeletal myxoid t(9;22)(q22:q12) EWS–CHN t(9;17)(q22:q11) RBP56–CHN t(9;15)(q22;q21)…
Molecular Studies
Genetic alteration PTC FTC PDCa AC FA Comment BRAF V600E mutations 45 % (classic>tall cell variant>follicular variant) 20 % 20 % >90 % BRAF mutations BRAF K601E mutations 3 %…
