Tumor type
Cytogenetic change
Fusion protein
Alveolar soft part sarcoma
t(X;17)(p11;q25)
ASPL–TFE3
Clear cell sarcoma/melanoma of soft parts
t(12;22)(q13;q12)
EWS–ATF1
t(2;22)(q34;q12)
EWS–CREB1
Chondrosarcoma, extraskeletal myxoid
t(9;22)(q22:q12)
EWS–CHN
t(9;17)(q22:q11)
RBP56–CHN
t(9;15)(q22;q21)
TCF12–CHN
Dermatofibrosarcoma protuberans
t(17;22)(q21;q13)
COL1A1–PDGFB
DPSRCT
t(11;22)(p13;q12)
EWS–WT1
Endometrial stromal sarcoma
t(7;17)(p15;q21)
JAZF1–JJAZ1
Ewing sarcoma/PNET
t(11;22)(q24;q12)
EWS–FLI1
t(21;22)(q22;q12)
EWS–ERG
t(7;22)(p22;q12)
EWS–ETV1
t(17;22)(q21;q12)
EWS–E1AF
t(2;22)(q33;q12)
EWS–FEV
Inflammatory myofibroblastic tumor
Translocations at 2p23 involving ALK gene
TPM3–ALK
TPM4–ALK
CLTC–ALK
Liposarcoma, myxoid/round cell
t(12;16)(q13;p11)
FUS/TLS–CHOP
t(12;22)(q13;q12)
EWS–CHOP
Liposarcoma, well differentiated
Marker ring or giant chromosomes 12q13-15; amplification of MDM2 and CDK4
Amplification of MDM2 and CDK4
PEComas
TFE3 rearrangement or amplification
TFE3
Rhabdomyosarcoma, alveolar
t(2;13)(q35;q14)
PAX3–FKHR
t(1;13)(p36;q14)
PAX7–FKHR
Rhabdomyosarcoma, embryonal
Trisomies, 2q, 8, and 20
None
Loss of heterozygosity at 11p15
none
Synovial sarcoma
t(X;18)(p11;q11)
SYT–SSX1
SYT–SSX2
SYT–SSX4
Wilms tumor
11p13 deletion/mutation
WT1
11p15 mutation
Trisomy 12
Abbreviations: DPSCT desmoplastic small round cell tumor, PEComas perivascular epithelioid cell neoplasms (including angiomyolipoma, clear cell sugar tumor, lymphangioleiomyomatosis), PNET primitive neuroectodermal tumor
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