Placenta and Gestational Trophoblastic Disease
Characteristics Partial mole Early complete mole Complete mole Ploidy 3 N 2 N 2 N Villous p57KIP2 positivity + − − Dimorphic villous populations + − − Dysmorphic villi +…
Tumors of Unknown Primary
(1) Department of Hematology Oncology, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA 92675, USA (2) Department of Pathology, Keck School of Medicine, University of Southern California, Los…
Lymph Node
Follicular hyperplasia Follicular lymphoma Younger patients Normal follicle density Older patients Increased follicle density (back to back) Follicles vary in size and shape Well-defined mantle zone Cellular polarization present Heterogeneous…
Diagnostic Electron Microscopy
Fig. 4.1. Lymphoma with convoluted nuclei. Nuclear inclusions exist in various forms Viruses may be visualized by negative staining of whole particles or in thin sections. See section on nonneoplastic…
Bone and Joints
Fig. 21.1. Myositis ossificans (gross) forming a circumscribed mass with a bony shell and a hemorrhagic fibrous center (A). Myositis ossificans (micro) at frozen section a well developed “zonation” is…
Mediastinum and Thymus
Fig. 26.1. (A) Mediastinal granuloma . Enlarged, matted lymph nodes replaced by fibrocaseous granulomas (scale = 1 cm). (B) Fibrocaseous granuloma with central cavitation within lymph node. (C) Budding yeast-like organisms consistent…
Renal Pelvis, Ureter, and Urethra
Fig. 37.1. Fibroepithelial polyp of the ureter. ♦ Chronic inflammatory cell infiltrate and xanthoma cells may be present Ureteral Endometriosis Clinical ♦ Mean age at diagnosis is 51…
Molecular Methodologies and Molecular Pathology of Hematolymphoid Neoplasms
Fig. 11.1. Detection of the translocation t(14;18) by FISH. Fluorescent probes specific for BCL2 (red), IGH (green), and the chromosome 18 centromere (aqua = control) were hybridized to tumor cell spreads. Panel…
Human Genetic Disorders
Fig. 13.1. Down syndrome – brushfield spots on irides (A). Single transverse palmar creases and fifth finger clinodactyly (B). Gap between first and second toe (C). ♦ Developmental delay,…
