Basicmedical Key

Thymic Carcinoma Key Facts Clinical Issues Generally poor prognosis High-grade tumors have median survival of 18 months Usual sites of metastases include lymph nodes, bone, lung, pleura, liver, and brain…

Synovial Sarcoma Key Facts Clinical Issues Predilection for young adults (median: 35 years) Female predilection (2:1) Aggressive behavior similar to soft tissue counterpart Microscopic Pathology Uniform and monotonous proliferation of…

Liposarcoma Key Facts Clinical Issues Rare tumor Broad age range; from children to adults (mean age: 43 years) Anterior and posterior mediastinum Dyspnea Chest pain Recurrences in 33% of cases…

Solitary Fibrous Tumor/Fibrosarcoma Key Facts Clinical Issues Most common mesenchymal spindle cell tumor of anterior mediastinum Cough Chest pain Dyspnea Hypoglycemia May be discovered incidentally on routine imaging studies Majority…

Acquired Multilocular Thymic Cyst Key Facts Etiology/Pathogenesis Acquired reactive process resulting from underlying infectious or inflammatory stimulus Clinical Issues Generally cured by complete surgical excision Rare cases can recur when…

Diffuse Large Cell Lymphoma of the Mediastinum Key Facts Clinical Issues Predominantly affects women in 3rd decade of life Presents with rapidly growing, large (> 10 cm in diameter), infiltrative…

Atypical Thymoma Key Facts Terminology WHO type B3, polygonal cell thymoma, well-differentiated thymic carcinoma Moderately differentiated thymic epithelial neoplasm intermediate between thymoma and thymic carcinoma Microscopic Pathology Confluent sheets of…

Thymoma Key Facts Clinical Issues Majority of thymomas are very low-grade malignant neoplasms with generally indolent behavior Status of capsular integrity is most important determinant factor for prognosis Microscopic Pathology…

Ganglioneuroma Key Facts Terminology Ganglioneuroma (GN) Benign tumor of neural origin Clinical Issues Incidence Tumor is more common in young patients Location More common in posterior mediastinum Symptomatology Chest pain…

Castleman Disease Key Facts Clinical Issues Most common in 3rd decade of life Localized type Presents as large mass involving lymph node or lymph node group Many patients are asymptomatic,…