Giant Cell Tumor of Tendon Sheath David R. Lucas, MD Key Facts Terminology Localized tenosynovial giant cell tumor, localized pigmented villonodular synovitis (PVNS), nodular tenosynovitis Benign soft tissue tumor of…
Juvenile Xanthogranuloma Elizabeth A. Montgomery, MD Key Facts Terminology Stable or regressing histiocytic lesion that usually occurs in childhood Form of non-Langerhans histiocytosis Clinical Issues Majority in individuals under 3…
Dermatofibroma (Benign Fibrous Histiocytoma) David S. Cassarino, MD, PhD Key Facts Terminology Benign limited proliferation of histiocytic and fibroblastic cells in dermis Etiology/Pathogenesis Evidence supports both neoplastic and reactive pathogenesis…
Deep Benign Fibrous Histiocytoma Elizabeth A. Montgomery, MD Key Facts Clinical Issues Painless mass of subcutaneous tissue Most common location is lower extremity Local recurrences common (about 20%) Rare metastases…
Sclerosing Epithelioid Fibrosarcoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Fibrosarcoma variant characterized by at least focal epithelioid cytomorphology and areas of dense fibrosis Clinical Issues Around periosteum or…
Low-Grade Fibromyxoid Sarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant fibroblastic neoplasm composed of bland spindles in collagenous matrix, often with prominent collagenous nodules Characterized by specific translocations…
Myxofibrosarcoma Thomas Mentzel, MD Key Facts Terminology Myxofibrosarcoma represents a spectrum of malignant fibroblastic neoplasms with variably myxoid stroma and characteristic elongated curvilinear vessels Clinical Issues One of the most…
Myxoinflammatory Fibroblastic Sarcoma Elizabeth A. Montgomery, MD Key Facts Clinical Issues Slow-growing infiltrative mass usually affecting distal extremities (hands and feet) of adults Recurrences are common, but metastases are rare…
Adult-Type Fibrosarcoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Soft tissue sarcoma composed of fibroblasts Lacks features of named fibrosarcoma subtypes Etiology/Pathogenesis Exceptionally rare if strictly defined Microscopic Pathology…
Low-Grade Myofibroblastic Sarcoma Thomas Mentzel, MD Key Facts Terminology Low-grade myofibroblastic sarcoma represents distinct atypical myofibroblastic neoplasm with fibromatosis-like morphologic features Clinical Issues Occurs frequently in head and neck region…
