Amyloidosis
Amyloidosis Kajsa Affolter, MD Key Facts Clinical Issues SA: Non-pruritic, waxy papules on scalp, neck, and, face with predilection for periorbital area and plaque-like lesions on hands and flexural areas…
Foreign Body Granuloma
Foreign Body Granuloma Brian J. Hall, MD John C. Hall, MD Key Facts Terminology Granulomatous inflammation as a response to traumatically introduced substances Clinical Issues Firm, usually colorless nodule that…
Granuloma Annulare
Granuloma Annulare Christine J. Ko, MD Key Facts Clinical Issues Most commonly localized over backs of hands/feet or on arms/legs Pink-red to slightly brown or purple 1-2 mm papules in…
Juvenile Xanthogranuloma
Juvenile Xanthogranuloma Christine J. Ko, MD Key Facts Microscopic Pathology Dermal nodule of mixed inflammation Predominantly histiocytes Varying morphologies: Vacuolated, xanthomatized, scalloped, oncocytic, spindle-shaped Admixed lymphocytes, eosinophils, occasional neutrophils and…
Necrolytic Migratory Erythema
Necrolytic Migratory Erythema Cary Chisholm, MD Key Facts Terminology Skin manifestation of glucagonoma syndrome Clinical Issues Trunk, groin, extremities, thighs, and buttocks are most frequently involved Annular or round erythematous…
Porphyria Cutanea Tarda
Porphyria Cutanea Tarda Michael W. Peterson, DO Cary Chisholm, MD Clay J. Cockerell, MD Key Facts Etiology/Pathogenesis Caused by deficiency in enzyme uroporphyrinogen decarboxylase Clinical Issues Hyperpigmentation, vesicles, bullae, and…
Relapsing Polychondritis
Relapsing Polychondritis Aparche Yang, MD, FAAD Sharon Jacob, MD Key Facts Terminology Chronic multisystem disease characterized by remitting and relapsing inflammation and destruction of cartilaginous and other proteoglycan-rich tissue Clinical…
Morphea/Scleroderma
Morphea/Scleroderma Sudeep Gaudi, MD Drazen M. Jukic, MD, PhD Key Facts Terminology Scleroderma limited to skin, subcutaneous tissue, and underlying muscle and bone Etiology/Pathogenesis Environmental trigger in a genetically predisposed…
Erythema Induratum
Erythema Induratum Cary Chisholm, MD Key Facts Terminology Granulomatous lobular panniculitis with vasculitis Etiology/Pathogenesis Mycobacterium species, Brucella species, hepatitis C Clinical Issues Usually multiple painful nodules on calves or shins…
Pseudoxanthoma Elasticum
Pseudoxanthoma Elasticum Irina Margaritescu, MD, DipRCPath Key Facts Terminology Inherited disorder characterized by fragmentation and progressive calcification of elastic tissue in dermis, blood vessels, and Bruch membrane of eye Microscopic…
