Cutaneous Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant soft tissue tumor that shows variable differentiation toward skeletal muscle 3 main subtypes Alveolar rhabdomyosarcoma (ARMS) Embryonal rhabdomyosarcoma (ERMS)…
Leiomyosarcoma Elizabeth A. Montgomery, MD Key Facts Terminology Malignant neoplasm composed of cells exhibiting smooth muscle differentiation Etiology/Pathogenesis Epstein-Barr virus associated in immunosuppressed patients Clinical Issues Superficial or deep soft…
Rhabdomyoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign tumor with skeletal muscle differentiation Extracardiac tumors can be of adult or fetal histologic type Etiology/Pathogenesis Some fetal rhabdomyomas associated…
Leiomyoma (Pilar) Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign cutaneous smooth muscle neoplasm arising from arrector pili muscles Etiology/Pathogenesis Many are shown to have germline fumarate hydratase gene…
Angioleiomyoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign neoplasm composed of blood vessels and smooth muscle cells in varying proportions Clinical Issues Most common between 40-60 years Mostly…
Superficial Malignant Peripheral Nerve Sheath Tumor David R. Lucas, MD Key Facts Terminology Superficial sarcoma arising from cutaneous nerve or benign nerve sheath tumor, or showing nerve sheath differentiation Etiology/Pathogenesis…
Congenital Smooth Muscle Hamartoma Steven D. Billings, MD Key Facts Terminology Rare lesion presenting in infants, characterized by disorganized proliferation of benign smooth muscle bundles in dermis, often involving subcutis…
Primary Neuroendocrine (Merkel Cell) Carcinoma David Cassarino, MD, PhD Key Facts Terminology Cutaneous neuroendocrine carcinoma Clinical Issues Highly aggressive tumors with greater metastatic potential than melanoma Rare (approximately 470 cases/year…
Protocol for Specimens of Merkel Cell Carcinoma of the Skin David Casarino, MD, PhD Merkel Cell Carcinoma of the Skin Incisional Biopsy, Excision, Reexcision, Lymphadenectomy Procedure ____ Biopsy, incisional ____…
Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor Alexandros D. Polydorides, MD, PhD Key Facts Terminology Rare malignant small round blue cell tumor Variable evidence of neuroectodermal differentiation Etiology/Pathogenesis From neural crest cells or…
