Microscopic Polyangiitis Surya V. Seshan, MD Key Facts Terminology Necrotizing vasculitis, with few or no immune deposits, affecting small arteries (capillaries, venules, or arterioles) Necrotizing glomerulonephritis is common Etiology/Pathogenesis ANCA-mediated…
Sarcoidosis Xin Gu, MD Key Facts Etiology/Pathogenesis Unclear etiology; disordered immune regulation Renal dysfunction related to nature and extent of involvement Clinical Issues More common in African-Americans than whites Involves…
Tuberous Sclerosis Aleksandr Vasilyev, MD, PhD Key Facts Etiology/Pathogenesis TSC1 gene, chromosome 9q34: Hamartin TSC2 gene, chromosome 16p13: Tuberin Chromosome 16p deletion may result in TSC2/PKD1 contiguous gene syndrome with…
Acquired Cystic Disease Anthony Chang, MD Aleksandr Vasilyev, MD, PhD Key Facts Terminology Presence of 3 or more cysts in native kidneys of patients with end-stage renal disease satisfies clinical…
Minimal Change Disease A. Brad Farris, III, MD Key Facts Terminology Synonyms: Lipoid nephrosis, nil disease Etiology/Pathogenesis Usually idiopathic Involves loss of glomerular negative charge Circulating permeability factor Secondary forms…
Nephrocalcinosis Lynn D. Cornell, MD Key Facts Terminology Deposition of abundant calcium phosphate precipitates within renal tubules and interstitium “Nephrocalcinosis” usually refers to calcium phosphate deposits in setting of hypercalcemia…
Mixed Cryoglobulinemic Glomerulonephritis A. Brad Farris, III, MD Key Facts Terminology GN due to immunoglobulins soluble at 37°C, reversibly precipitate with cooling Etiology/Pathogenesis Renal disease usually type II mixed cryoglobulinemia…
Fibromuscular Dysplasia A. Brad Farris, III, MD Key Facts Terminology Nonatherosclerotic, noninflammatory fibrous, and fibromuscular proliferation of artery, typically leading to stenosis Clinical Issues Mostly young and female 60-90% involve…
Introduction to Impediments to Urine Flow Sanjay Jain, MD, PhD This illustration depicts the different causes (urinary tract intrinsic or extrinsic) of impediments to urine flow. The lesions can arise…
Takayasu Arteritis Surya V. Seshan, MD Key Facts Terminology Granulomatous inflammation of aorta and its major branches Etiology/Pathogenesis Cell-mediated immune mechanism Clinical Issues Common in Asia (6/1,000) compared with USA…
