Acquired Cystic Disease



Acquired Cystic Disease


Anthony Chang, MD

Aleksandr Vasilyev, MD, PhD










Axial CECT shows innumerable cysts in bilaterally enlarged kidneys of a patient who has been on dialysis for many years.






Multiple cysts image are located throughout this end-stage kidney from a dialysis patient. This native kidney was removed for a suspicious mass image, which demonstrated both clear cell and papillary features.


TERMINOLOGY


Abbreviations



  • Acquired cystic disease (ACD)


Synonyms



  • Acquired cystic kidney disease


  • Acquired cystic renal disease


Definitions



  • Presence of 3 or more cysts in native kidneys of patients with end-stage renal disease satisfies clinical diagnosis of ACD


ETIOLOGY/PATHOGENESIS


Unknown Pathogenesis



  • Believed to involve physiologic response to chronic renal failure



    • Possible uncharacterized humoral factor



      • Successful renal transplantation may decrease size of cysts


    • Increased proliferation of cyst-lining epithelium


  • Unclear role of calcium oxalate crystals


  • Not necessarily secondary to dialysis



    • Cyst formation occurs in some patients even before dialysis therapy


CLINICAL ISSUES


Epidemiology



  • Incidence



    • 60-80% of patients on dialysis for more than 4 years may be diagnosed with ACD


  • Age



    • All ages


  • Gender



    • Male predilection


  • Ethnicity



    • Africans may be more likely than Caucasians to develop ACD

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Acquired Cystic Disease
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