Fibrillary Glomerulopathy

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Fibrillary Glomerulopathy

Fibrillary Glomerulopathy Anthony Chang, MD Key Facts Clinical Issues Rare: < 1% of native kidney biopsies Associated with malignancy, dysproteinemia, and autoimmune disease Proteinuria (100%) Hematuria (˜ 50%) 40-50% progress…

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Multilocular Cystic Nephroma

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Multilocular Cystic Nephroma

Multilocular Cystic Nephroma Aleksandr Vasilyev, MD, PhD Key Facts Terminology Multilocular cystic nephroma (MCN) Cystic nephroma (CN), multilocular cyst Etiology/Pathogenesis Relationship to sex hormones is suggested Clinical Issues Female:male ratio…

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Oculocerebrorenal Syndrome of Lowe

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Oculocerebrorenal Syndrome of Lowe

Oculocerebrorenal Syndrome of Lowe Ami Bhalodia, MD Key Facts Terminology Oculocerebrorenal syndrome (OCRL) Etiology/Pathogenesis Inherited mutation caused by OCRL1 gene mutation Affects protein trafficking and cellular metabolism Clinical Issues X-linked…

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Polyarteritis Nodosa

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Polyarteritis Nodosa

Polyarteritis Nodosa Surya V. Seshan, MD Key Facts Terminology Necrotizing inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or venules Clinical Issues HBV association in…

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Sickle Cell Disease

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Sickle Cell Disease

Sickle Cell Disease Anthony Chang, MD Key Facts Terminology Sickle cell nephropathy Etiology/Pathogenesis β-globin gene mutation Chromosome 11p15.5 Clinical Issues Presentation Chronic kidney disease Proteinuria Drugs Angiotensin-converting enzyme inhibitors Macroscopic…

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Loin Pain Hematuria Syndrome

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Loin Pain Hematuria Syndrome

Loin Pain Hematuria Syndrome Xin Gu, MD Key Facts Etiology/Pathogenesis Unknown or tubular obstruction from intranephron hemorrhage Clinical Issues LPHS is a diagnosis of exclusion Microscopic Pathology Normal or nonspecific…

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Aspergillosis

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Aspergillosis

Aspergillosis Anthony Chang, MD Key Facts Etiology/Pathogenesis A. fumigatus A. flavus A. niger Clinical Issues Treatment Renal allograft nephrectomy Nephrostomy drainage and systemic antifungal therapy Voriconazole Incidence 0.1% in kidney…

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Osmotic Tubulopathy

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Osmotic Tubulopathy

Osmotic Tubulopathy Shane M. Meehan, MBBCh Key Facts Terminology Tubular epithelial swelling and isometric vacuolization, associated with exposure to parenteral carbohydrate solutions or contrast media, and acute kidney injury Etiology/Pathogenesis…

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