Basicmedical Key

Veno-occlusive Disease Sanjay Kakar, MD Key Facts Etiology/Pathogenesis Stem cell transplantation and high-dose chemotherapy Sinusoidal endothelial cell injury is important initial event Clinical Issues Hyperbilirubinemia, weight gain, and painful hepatomegaly…

Portal Venous Obstruction Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Can occur at any level of portal venous system Extrahepatic: Portal trunk or large tributaries, usually caused by thrombosis Intrahepatic:…

NASH Matthew M. Yeh, MD, PhD Key Facts Etiology/Pathogenesis Associated conditions Diabetes, obesity, hyperlipidemia, dyslipidemia, drugs, malabsorption, malnutrition Clinical Issues Patients often have metabolic syndrome Transaminases usually elevated May have…

Drug-related Steatohepatitis/Phospholipidosis Laura Webb Lamps, MD Key Facts Terminology Definition: Steatohepatitis as consequence of drug exposure Etiology/Pathogenesis Commonly implicated drugs Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues Symptoms may present…

Drug-induced Acute Hepatic Failure Sanjay Kakar, MD Key Facts Terminology Onset of hepatic encephalopathy within 8 weeks of onset of symptoms INR is > 1.5, and there is no evidence…

Drug-related Granulomatous Hepatitis Laura Webb Lamps, MD Key Facts Clinical Issues Drug-induced hepatic injury can mimic any other form of liver disease Microscopic Pathology Noncaseating granulomas Presence of granulomas, ±…

Paucity of Intrahepatic Bile Ducts (Nonsyndromic) Joseph Misdraji, MD Key Facts Terminology Heterogeneous group of disorders that causes bile duct paucity in patients without congenital abnormalities indicative of Alagille syndrome…

Drug-related Acute Hepatitis Sanjay Kakar, MD Key Facts Etiology/Pathogenesis 2 chief mechanisms: Intrinsic and idiosyncratic Herbal and botanical drugs are important but often overlooked cause of hepatotoxicity Clinical Issues Classified…

Idiopathic Adulthood Ductopenia Joseph Misdraji, MD Key Facts Terminology Ductopenia in adult without known cause or clinicopathologic features of specific etiology Clinical Issues Presents with episodic jaundice and pruritus Can…

Idiopathic Neonatal Hepatitis Grace E. Kim, MD Key Facts Terminology Convenient term for clinical condition manifested by prolonged jaundice in neonates with variable but definable histologic picture Microscopic Pathology Predominately…