Idiopathic Neonatal Hepatitis

Idiopathic Neonatal Hepatitis

Grace E. Kim, MD

The characteristic features of INH include lobular giant cell transformation and extramedullary hematopoiesis. Ductular reaction is absent, and hepatocyte necrosis may not be apparent.

INH is primarily a lobular process with hepatocytes showing giant cell change and necrosis image along with cholestasis image.



  • Idiopathic neonatal hepatitis (INH)


  • General term for clinical condition manifested by prolonged jaundice in neonates with variable but definable histologic picture

    • Clinicopathologic picture is termed “neonatal hepatitis syndrome”

    • Uniform clinical presentation but broad spectrum of causative disease processes

    • INH is diagnosis of exclusion


Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Idiopathic Neonatal Hepatitis
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