Eosinophilic Cholecystitis Vikram Deshpande, MD Key Facts Terminology Inflammatory disease of gallbladder in which inflammatory infiltrate is composed predominantly of eosinophils Microscopic Pathology Dense eosinophilic infiltrate of gallbladder with or…
Xanthogranulomatous Cholecystitis Laura Webb Lamps, MD Key Facts Terminology Variant of chronic cholecystitis characterized by granulomatous reaction to bile Macroscopic Features Cream to brown tumor-like masses, nodules, or plaques Usually…
Chronic Cholecystitis Kari D. Caradine, MD Key Facts Etiology/Pathogenesis Almost always associated with gallstones Clinical Issues More common in women; approximately 3:1 Microscopic Pathology Predominantly mononuclear inflammatory infiltrate with lymphocytes…
Acute Cholecystitis Vikram Deshpande, MD Key Facts Etiology/Pathogenesis Acute calculous cholecystitis: 95% of cases Acute acalculous cholecystitis: 5% of cases Clinical Issues Right upper quadrant pain, tenderness, and guarding Fever,…
Cholelithiasis Kari D. Caradine, MD Key Facts Terminology Stones in gallbladder or common bile duct Classified by chemical composition into 2 main types: Cholesterol stones and pigment stones Clinical Issues…
Choledochal Cyst Laura Webb Lamps, MD Key Facts Terminology Cystic dilatation of biliary tract, usually extrahepatic Clinical Issues Usually presents in childhood; most patients female Most common in Japan Jaundice,…
Nesidioblastosis Vikram Deshpande, MD Key Facts Terminology Morphologic findings associated with functional disorders of β cells (hyperinsulinemic hypoglycemia) in absence of insulinoma Etiology/Pathogenesis Abnormalities in potassium channels Clinical Issues Persistent…
Cystic Fibrosis, Pancreas Mari Mino-Kenudson, MD Key Facts Etiology/Pathogenesis Cystic fibrosis transmembrane conductance regulator (CFTR) gene on chromosome 7q31.2 Clinical Issues Exocrine pancreatic insufficiency occurs in majority of patients Macroscopic…
Congenital Pancreatic Cyst Grace E. Kim, MD Key Facts Terminology Rare benign congenital epithelial-lined cyst that is not associated with ductal obstruction or other pancreatic anomalies Does not communicate with…
Langerhans Cell Histiocytosis Joseph Misdraji, MD Key Facts Etiology/Pathogenesis Clonal proliferation of Langerhans dendritic cells Clinical Issues Affects infants and children Multisystem LCH can involve “risk” organs: Liver, spleen, hematopoietic…
