Noncirrhotic background liver • Central stellate scar with radiating septa Microscopic • Localized nodular parenchyma with fibrous septa and stellate central scar Septa contain thick-walled vessels and mononuclear inflammatory infiltrate • Ductular reaction…
Manifestations vary with severity and rapidity of ischemic insult Causes include arterial thrombosis, surgical injury, hypotension Clinical Issues • Prognosis varies depending on rapidity and extent of ischemic insult Severe acute…
No grossly visible mucin Clinical Issues • Very rare entity • Majority are discovered incidentally • Age Range: 36-79 years Average: 59 years • Presentation Similar to intraductal papillary mucinous neoplasms (IPMNs) – Symptomatic cases…
Results in bile duct ischemia, hepatic parenchymal infarction – Bile ducts depend on arterial flow and therefore suffer ischemic injury Clinical Issues • Relatively well tolerated in native livers Anastomosing blood supply…
Prolonged storage in preservation solutions • Warm ischemia Compromised blood flow to liver at body temperature before and during harvesting Resumption of blood flow after implantation Clinical Issues • Elevation of serum…
Possibly congenital malformation Clinical Issues • Usually presents in childhood before age 10 75% of patients are female Very common in Asian populations, particularly in Japan • Jaundice, abdominal pain, mass are…
Liver involvement is usually feature of disseminated disease Most common in, but not limited to, immunocompromised patients Etiology/Pathogenesis • Worldwide distribution and widespread in nature • Ubiquitous soil saprophyte; acquired by inhalation…
Hepatic TB seen in ∼ 1% of patients with active TB More common in HIV(+) patients Etiology/Pathogenesis • Transmission typically by inhalation Can reach liver by hematogenous spread or direct spread…
Most common nonepithelial tumor of extrahepatic bile ducts Clinical Issues • Occur most often in young African American women Mean age: 34.7 years • Most frequent location is common bile duct • Often…
S. mansoni and S. japonicum most frequently cause hepatosplenic disease Etiology/Pathogenesis • Infection occurs when cercariae (infectious larvae) leave intermediate host snail and penetrate skin of vertebrate host (in contaminated water)…
