Results in bile duct ischemia, hepatic parenchymal infarction
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Bile ducts depend on arterial flow and therefore suffer ischemic injury
Clinical Issues
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Relatively well tolerated in native livers
Anastomosing blood supply with good collateralization protects against ischemic injury
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Transplanted livers much more susceptible, especially early post transplant
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Symptoms related to acuity and ensuing complications
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Cholestatic liver function abnormalities are common
Microscopic
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Zone 3 hemorrhage and hepatocyte dropout in early posttransplant period
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Ischemic bile duct injury
Denuded, necrotic bile duct epithelium sloughs into lumen, forming eosinophilic bile casts
Bile leakage into periductal connective tissue
In time, chronic ischemia can lead to biliary strictures, fibrosis, and duct loss
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Hepatic infarction
Necrosis of hepatocytes and portal connective tissue
TERMINOLOGY
Abbreviations
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Hepatic artery thrombosis (HAT)
Definitions
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Thrombotic occlusion of hepatic artery &/or its branches
ETIOLOGY/PATHOGENESIS
Causes of Thrombosis
following hepatic artery thrombosis.
in a patient who developed hepatic artery thrombosis after transplantation.
and leakage of bile 
. The bile duct ischemia occurred secondary to hepatic artery thrombosis.
