Dialysis-Associated Amyloidosis
Fig. 6.1 Prevalence of β2 mamyloid deposits at autopsy according to duration of dialysis. The autopsy was performed on osteoarticular specimens obtained from 54 deceased patients who had received long-term…
Non-Randall Glomerulonephritis with Non-Organized Monoclonal Ig Deposits
Organized deposits Non-organized deposits Type-1 cryoglobulinemic GN Light and heavy chain deposition disease (LHCDD) Immunotactoid GN Proliferative GN with monoclonal Ig deposits(PGNMID) Light and heavy chain amyloidosis (Fibrillary GN) Nonproliferative…
Amyloidosis from the Patient’s Perspective
Age and sex at dx Interval from symptoms to dx How long did it take to type it Initial symptoms What bx was diagnostic, how many? What was your life…
Medicolegal Issues of Amyloidosis
© Springer International Publishing Switzerland 2015Maria M. Picken, Guillermo A. Herrera and Ahmet Dogan (eds.)Amyloid and Related DisordersCurrent Clinical Pathology10.1007/978-3-319-19294-9_39 39. Medicolegal Issues of Amyloidosis Timothy Craig Allen1 (1) Department of Pathology, The University of Texas Medical Branch,…
Modern Therapies in AA Amyloidosis
Anti-TNF medication Type Administered Diseases treated AA amyloidosis treatment Infection risk Use with caution in patients with Monitoring Antibody, autoimmune associations Etanercept Soluble p75 TNFR:Fc fusion protein Subcutaneous RA AS…
Emerging Therapies for Amyloidosis
Drug Toxicity Melphalan (Alkeran) (oral) Bone marrow suppression Myelodysplastic syndrome Melphalan (IV with stem-cell rescue) Bone marrow suppression Infection Bortezomib (Velcade) Neuropathy Lenalidomide (Revlimid) Thrombocytopenia GI dysmotility Deep venous thrombosis…
Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis
Fig. 2.1 Mechanisms of amyloid formation and toxicity. Intrinsic instability, increased concentration, mutations, proteolytic cleavage or a combination thereof can favour the conversion of the amyloidogenic precursor into its misfolded…
Leukocyte Cell-Derived Chemotaxin 2 Amyloidosis (ALECT2)
Fig. 4.1 Kidney and liver ALECT2 amyloidosis. Eosinophilic amyloid deposits in the kidney with glomerular, interstitial, and vascular involvement (a, H&E) stain with Congo red (b). Congo red stain viewed…
Aspects of the History and Nomenclature of Amyloid and Amyloidosis
Fibril protein Precursor protein Systemic and/or localized Acquired or hereditary Target organs AL Immunoglobulin light chain S, L A, He All organs except CNS (Local AL amyloidosis may occur) AH…
