Fig. 24.1 Virtual 2D map, showing the distribution of proteins identified by LC-MS in a representative subcutaneous fat tissue aspirate, according to isoelectric point and molecular weight. The inset and…
Disease Gene Inheritance Flare duration Fever Cutaneous manifestations Abdominal manifestations Pulmonary Arthritis arthralgias Neurologic AA Amyloidosis FMF MEFV AR 1–3 days Yes Erysipeloid erythema Pain, constipation, diarrhea Pleurisy Yes No…
Type Pathology Genetics Clinical Aβ Diffuse plaques Neuritic plaques/NFTs CAA (mild) Down’s AβPP Swe690/691 AβPP V717 Dementia Aβ CAA (severe) AβPP Dutch mutations Lobar hemorrhages, ± dementia BR12 Plaques, NFTs,…
Fig. 17.1 Fat needle biopsy. Congo red-stained slide viewed under polarized light showing apple green as well as yellow anomalous colors. Specimen obtained using a 16-gauge needle (Reprinted with permission…
Fig. 36.1 An algorithm for the evaluation of suspected amyloidosis [2]. Reprinted with permission. © 2008 American Society of Clinical Oncology. All rights reserved. Merlini G et al. J Clin…
Fig. 25.1 (a) Protein Electrophoresis (PEL) and Immunofixation electrophoresis (IFE) of normal serum: the proteins in the gamma fraction on the PEL gel and the precipitated immunoglobulins on the IFE…
Fig. 21.1 In microphotographs (a) heart, (b) heart, and (c) kidney amyloid deposits are seen by Congo staining. Microphotographs (d), (e), and (f) show: lambda light chain deposits (d), transthyretin…
Fig. 15.1 (a) Vessel wall, with deposits of amyloid, in renal AL amyloidosis. Congophilia (salmon-pink color) is noted in the vessel wall, corresponding to amyloid deposits. Congo red stain, bright…
Fig. 35.1 AIns amyloidosis secondary to subcutaneous insulin injection to control diabetes. The incisional subcutaneous biopsy shows extensive deposition of eosinophilic extracellular material in the subcutaneous adipose tissue (low and…
Fig. 27.1 Gene sequencing for ApoA1 showing c. 296T>C, p. Leu99Pro pathogenic mutation in exon 4. The top and bottom sequences (1 and 4) are the reference sequences against which…
