Syringofibroadenoma
Senait W. Dyson, MD
Key Facts
Clinical Issues
Commonly on an extremity
More common in women
Usually solitary, hyperkeratotic plaque
Multiple lesions might be associated with rare syndromes
Microscopic Pathology
Vertically oriented, slender, interconnected basaloid epithelial cords extending from epidermis
Lumina formation can be present
Embedded in fibrovascular stroma
Top Differential Diagnoses
Basal cell carcinoma (fibroepithelioma of Pinkus variant)
Poroma
Hidroacanthoma simplex
Acrosyringeal nevus
Syringofibroadenocarcinoma
 Arising from multiple points along the epidermis are anastomosing cords  of uniform epithelial cells embedded in a fibrovascular stroma, findings typical of SFA. |
 Epithelial strands of acrosyringeal cells with ductal formation  in fibrovascular stroma  is a characteristic finding of SFA. |
TERMINOLOGY
Abbreviations
Syringofibroadenoma (SFA)
Synonyms
Eccrine syringofibroadenoma (of Mascaro), acrosyringeal adenomatosis
Definitions
Rare benign tumor of eccrine ductal origin
CLINICAL ISSUES
Epidemiology
Age
Commonly in elderly
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