Syringofibroadenoma
Senait W. Dyson, MD
Key Facts
Clinical Issues
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Commonly on an extremity
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More common in women
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Usually solitary, hyperkeratotic plaque
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Multiple lesions might be associated with rare syndromes
Microscopic Pathology
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Vertically oriented, slender, interconnected basaloid epithelial cords extending from epidermis
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Lumina formation can be present
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Embedded in fibrovascular stroma
Top Differential Diagnoses
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Basal cell carcinoma (fibroepithelioma of Pinkus variant)
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Poroma
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Hidroacanthoma simplex
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Acrosyringeal nevus
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Syringofibroadenocarcinoma
Arising from multiple points along the epidermis are anastomosing cords  of uniform epithelial cells embedded in a fibrovascular stroma, findings typical of SFA. |
Epithelial strands of acrosyringeal cells with ductal formation  in fibrovascular stroma  is a characteristic finding of SFA. |
TERMINOLOGY
Abbreviations
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Syringofibroadenoma (SFA)
Synonyms
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Eccrine syringofibroadenoma (of Mascaro), acrosyringeal adenomatosis
Definitions
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Rare benign tumor of eccrine ductal origin
CLINICAL ISSUES
Epidemiology
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Age
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Commonly in elderly
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