Squamous/Adenosquamous Carcinoma, Pancreas

 Glandular component may contain conventional ductal-type, clear cell, or signet ring cell components

Ancillary Tests

• p63 is positive in squamous component
• Mucin stain, CK7, CK20, CEA, and CA19-9 highlight adenocarcinoma component

Top Differential Diagnoses

• Metastatic squamous cell carcinoma
• Pancreatoblastoma
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Solid-Cystic MassPrimary adenosquamous cell carcinoma in the tail of the pancreas shows a relatively well-demarcated, tan-white to yellow solid mass image with a cystic component image .

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Squamous and Glandular AreasAdenosquamous cell carcinoma of the pancreas demonstrates islands of malignant squamous cells with keratinization image adjacent to high-grade pancreatic intraepithelial neoplasia involving an interlobular duct image .
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p63 StainImmunohistochemical stain for p63 shows nuclear staining in the squamous component image of adenosquamous cell carcinoma, while the glandular component is negative image .
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CEA StainImmunohistochemical stain for carcinoembryonic antigen highlights the glandular component image, while the squamous component image is negative.

TERMINOLOGY

Synonyms

• Adenoacanthoma
• Mixed squamous/adenocarcinoma
• Mucoepidermoid carcinoma

Definitions

• Uncommon variant of pancreatic cancer with both glandular and squamous differentiation
image Pure squamous cell carcinoma of pancreas is vanishingly rare

ETIOLOGY/PATHOGENESIS

Neoplastic

• A few hypotheses attempt to explain origin of squamous component
image Squamous metaplasia of pancreatic duct epithelium
image Both components derive from common progenitor

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Apr 20, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Squamous/Adenosquamous Carcinoma, Pancreas

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