Pseudohyperplastic Carcinoma
Antonio L. Cubilla, MD
Alcides Chaux, MD
Elsa F. Velazquez, MD
Key Facts
Etiology/Pathogenesis
Strong association with lichen sclerosus
Macroscopic Features
Foreskin location
Multicentricity
Tumor with flat or slightly elevated hyperkeratotic surface
Microscopic Pathology
Extremely well-differentiated carcinoma
Flat or slightly elevated surface
Background of LS
Top Differential Diagnoses
Verrucous carcinoma
Pseudoepitheliomatous hyperplasia
 Well-differentiated pseudohyperplastic SCC is seen with flat to polypoid surface and downward proliferation of irregular nests. The differential diagnosis is with pseudoepitheliomatous hyperplasia. |
 Appreciation of infiltrative tongues of well-differentiated tumor that invade the subepithelial connective tissue helps distinguish pseudohyperplastic carcinoma from a pseudoneoplastic lesion. |
TERMINOLOGY
Abbreviations
Squamous cell carcinoma (SCC)
Synonyms
Pseudohyperplastic squamous cell carcinoma
Definitions
Nonverruciform low-grade SCC preferentially affecting foreskin of older patients and strongly associated with lichen sclerosus (LS)
ETIOLOGY/PATHOGENESIS
Pathogenesis
Unknown
Probably unrelated to HPV
Strong association with LS
