Endodermally derived epithelial cells originating from ventral primordium of pancreas (hamartomatous proliferation)
Diagnostic Checklist
Periampullary gangliocytic paragangliomas
often have an infiltrating pattern at the periphery as shown here at low-power magnification. The lesion is centered in the submucosa with extension into the overlying mucosa 
.
Gangliocytic paraganglioma (high-power magnification) consisting of a mixture of epithelioid cells, ganglion-like cells
, and nerve sheath elements 
is shown.
Ganglion-like cells
with dense cytoplasm, open chromatin, and prominent nucleoli are indistinguishable from normal ganglion cells. Nerve sheath elements 
contain Schwann cells with elongated nuclei and vacuolated cytoplasm. Neural filaments are not well visualized.
TERMINOLOGY
Synonyms
Definitions
• Neoplasm consisting of epithelioid, ganglion-like cells and nerve sheath elements
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