Slightly dilated and irregular in shape
Lined by single layer of bland endothelial cells
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Secondary involutional changes in central portion
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Peripheral cellular areas show proliferation of vascular channels in loose fibrous stroma
Ancillary Tests
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Positive for vascular markers: Factor VIII, CD31, CD34, FLI-1
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GLUT-1 is often positive, while most vascular malformations are negative
TERMINOLOGY
Synonyms
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Originally described by Dehner and Ishak as infantile hemangioendothelioma type 1
Definitions
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Hepatic vascular neoplasm
Most common hepatic neoplasm during 1st year of life
Accounts for 15% of primary liver tumors in pediatric population
CLINICAL ISSUES
Epidemiology
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Age
Most present before age of 6 months
Rare in adults