Once known etiologies are excluded, then considered idiopathic
• By mid-2000s, idiopathic neonatal hepatitis (INH) comprised only 15-30% of neonatal cholestasis due to increased ability to detect and diagnose metabolic and genetic disorders previously considered idiopathic
Top Differential Diagnoses
![image](/wp-content/uploads/2017/04/image01985.jpeg)
The characteristic features of idiopathic neonatal hepatitis include lobular giant cell transformation and prominent extramedullary hematopoiesis. Portal changes are minimal, and ductular reaction is absent.
![image](/wp-content/uploads/2017/04/image01986-1.jpeg)
The lobular hepatocytes show giant cell change and scattered apoptotic hepatocytes
![image](/wp-content/uploads/2017/04/image01987-1.jpeg)
![image](/wp-content/uploads/2017/04/image01988-1.jpeg)
![image](/wp-content/uploads/2017/04/image01989-1.jpeg)
This case of neonatal hepatitis due to CMV shows a few giant cell hepatocytes along with extramedullary hematopoiesis. A single CMV inclusion
![image](/wp-content/uploads/2017/04/image01988-2.jpeg)
TERMINOLOGY
Abbreviations
Definitions
• General term for clinical condition manifested by prolonged jaundice in neonates with variable but definable histologic picture
![](https://freepngimg.com/download/social_media/63059-media-icons-telegram-twitter-blog-computer-social.png)
![](https://freepngimg.com/download/social_media/63059-media-icons-telegram-twitter-blog-computer-social.png)
Stay updated, free articles. Join our Telegram channel
![](https://clinicalpub.com/wp-content/uploads/2023/09/256.png)
Full access? Get Clinical Tree
![](https://videdental.com/wp-content/uploads/2023/09/appstore.png)
![](https://videdental.com/wp-content/uploads/2023/09/google-play.png)
![](https://clinicalpub.com/wp-content/uploads/2023/09/banner1.png)