Glycogenic Hepatopathy

 Pale, enlarged hepatocytes may be mistaken for normal or interpreted as fixation artifact

• Fatty liver disease
image Pale, enlarged hepatocytes may be misinterpreted as ballooning hepatocyte degeneration

• Glycogen storage disease
image No history of diabetes mellitus

Pale Swollen Hepatocytes Without Inflammation
Needle biopsy of the liver shows diffuse hepatocyte swelling, imparting an overall pale appearance. Steatotic vacuoles are absent or rare. There is no lobular inflammation.

Cytologic Features
Liver biopsy from a patient with glycogenic hepatopathy shows diffuse enlargement of hepatocytes with pale, wispy cytoplasm and prominent cytoplasmic membranes image. Glycogenated hepatocyte nuclei image are common.

Sparing of Portal Tracts
The portal tracts appear normal in glycogenic hepatopathy image. They contain their normal structures, and there are no portal inflammatory cell infiltrates. The background hepatocytes image are diffusely swollen and filled with glycogen.

Hepatocytes: PAS Stain
PAS stain highlights the abundant glycogen in hepatocytes in a liver biopsy from a patient with glycogenic hepatopathy.



• Hepatic glycogenosis
• Liver glycogenosis

• Glycogen hepatopathy

• Diabetes mellitus-associated glycogen storage hepatomegaly

• Mauriac syndrome

image Liver changes accompanied by growth retardation, delayed puberty, hypercholesterolemia, and cushingoid features


• Excessive glycogen storage in hepatocytes secondary to poorly controlled insulin-dependent diabetes mellitus


Metabolic Factors

Apr 20, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Glycogenic Hepatopathy

Full access? Get Clinical Tree

Get Clinical Tree app for offline access
%d bloggers like this: